| Title: | Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study |
| Journal: | Alzheimer's & Dementia |
| Published: | 3 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34978125/ |
| DOI: | https://doi.org/10.1002/alz.12529 |
Publication 13840
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Abstract
INTRODUCTION: The association of testosterone concentrations with dementia risk remains uncertain. We examined associations of serum testosterone and sex hormone-binding globulin (SHBG) with incidence of dementia and Alzheimer's disease.</p>
METHODS: Serum total testosterone and SHBG were measured by immunoassay. The incidence of dementia and Alzheimer's disease (AD) was recorded. Cox proportional hazards regression was adjusted for age and other variables.</p>
RESULTS: In 159,411 community-dwelling men (median age 61, followed for 7 years), 826 developed dementia, including 288 from AD. Lower total testosterone was associated with a higher incidence of dementia (overall trend: P = .001, lowest vs highest quintile: hazard ratio [HR] = 1.43, 95% confidence interval [CI] = 1.13-1.81), and AD (P = .017, HR = 1.80, CI = 1.21-2.66). Lower SHBG was associated with a lower incidence of dementia (P < .001, HR = 0.66, CI = 0.51-0.85) and AD (P = .012, HR = 0.53, CI = 0.34-0.84).</p>
DISCUSSION: Lower total testosterone and higher SHBG are independently associated with incident dementia and AD in older men. Additional research is needed to determine causality.</p>
12 Keywords
- Aged
- Alzheimer Disease
- Biological Specimen Banks
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Sex Hormone-Binding Globulin
- Testosterone
- United Kingdom
19 Authors
- Ross J. Marriott
- Kevin Murray
- Leon Flicker
- Graeme J. Hankey
- Alvin M. Matsumoto
- Girish Dwivedi
- Leen Antonio
- Osvaldo P. Almeida
- Shalender Bhasin
- Adrian S. Dobs
- David J. Handelsman
- Robin Haring
- Terence W. O'Neill
- Claes Ohlsson
- Eric S. Orwoll
- Dirk Vanderschueren
- Gary A. Wittert
- Frederick C.W. Wu
- Bu B. Yeap
1 Application
| Application ID | Title |
|---|---|
| 54680 | Sex hormones as predictors of key health outcomes in men from the UK Biobank |
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