| Title: | Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: A prospective cohort study within UK Biobank |
| Journal: | United European Gastroenterology Journal |
| Published: | 1 Oct 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30288276/ |
| DOI: | https://doi.org/10.1177/2050640618783558 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1177/2050640618783558 |
Publication 13747
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Abstract
BACKGROUND: Few observational studies have assessed the role of physical activity in oesophago-gastric cancer risk.</p>
OBJECTIVE: This prospective cohort study aimed to assess the association between physical activity and risk of oesophageal or gastric cancer.</p>
METHODS: A cohort of 359,033 adults aged 40-69 years were identified from the UK Biobank, which recruited participants between 2006 and 2010. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between self-reported levels of physical activity and screen-based sedentary behaviour and risk of oesophageal and gastric cancer were calculated using Cox proportional hazards models.</p>
RESULTS: During eight years of follow-up (mean = 5.5), 294 oesophageal cancer and 217 gastric cancer cases were identified. Physical activity and screen-based sedentary behaviour levels were not associated with overall oesophago-gastric cancer risk. However, when compared with low levels, high physical activity levels were associated with a significantly reduced risk of gastric non-cardia cancer (HR 0.58, 95% CI 0.37-0.95). Moderate physical activity levels were associated with a 38% reduced risk of oesophageal adenocarcinoma (HR 0.62, 95% CI 0.43-0.89), although no dose-response association was apparent.</p>
CONCLUSION: Moderate, rather than high, physical activity levels were associated with the strongest reductions in oesophageal adenocarcinoma risk in this large UK prospective cohort.</p>
7 Authors
- Andrew T Kunzmann
- Kristian P Mallon
- Ruth F Hunter
- Chris R Cardwell
- Úna C McMenamin
- Andrew D Spence
- Helen G Coleman
1 Application
| Application ID | Title |
|---|---|
| 34374 | Risk factors and biomarkers for the development and early diagnosis of upper gastro-intestinal cancers |
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