| Title: | Serum Phosphate in the General Population: A Need for Sex-Specific Reference Intervals |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 16 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39283962/ |
| DOI: | https://doi.org/10.1210/clinem/dgae633 |
Publication 13551
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Abstract
BACKGROUND: Phosphate is important for several metabolic functions and essential for bone mineralization. Sex-differences exist in the relation between serum phosphate and certain diseases. The reference interval for phosphate is age-adjusted in infants, but most institutions use the same intervals for adult men and women despite increasing evidence for age and sex-differences. We aimed to study these differences in two large population-based cohorts in order to evaluate whether current reference intervals are adequate.</p>
METHODS: 8837 participants from three cohorts of the Rotterdam Study (RS) and 422,443 participants from UK Biobank (UKBB), aged 40 and older and without chronic kidney disease, were analyzed for sex/differences in serum phosphate using standard reference values (0.8-1.45 mmol or 2.5-4.5 mg/dL). Analyses were further stratified in women by menopausal status.</p>
RESULTS: Women had higher serum phosphate concentrations and a higher population range compared to men in all cohorts. Hypophosphatemia was more prevalent in men and hyperphosphatemia was more prevalent in women. Sex-differences were present in all age-categories. Perimenopausal women had higher serum phosphate concentrations than men of the same age, but lower than postmenopausal women of the same age.</p>
CONCLUSIONS: This study in two population-based cohorts showed that women have higher serum phosphate concentrations than men and that women show a marked increase in serum phosphate during menopause. Moreover, the population range for serum phosphate was higher in women than in men. These findings indicate a need for sex-specific reference intervals for serum phosphate in adults older than 45 years.</p>
4 Authors
- Ariadne Bosman
- Natalia Campos-Obando
- Christian Ramakers
- M Carola Zillikens
1 Application
| Application ID | Title |
|---|---|
| 48264 | Exploring the genetic determinants of serum phosphate through large-scale GWAS Biobank approach: towards the elucidation of the genetic architecture of human serum phosphate |
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