| Title: | Impact of Replacing Sedentary Behavior with Physical Activity and Sleep on Stroke Risk: A Prospective Cohort Study |
| Journal: | Nature and Science of Sleep |
| Published: | 1 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39421151/ |
| DOI: | https://doi.org/10.2147/nss.s482276 |
Publication 13309
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Abstract
Objective: Our research explores how leisure-time sedentary behavior (SB) correlates with stroke risk. Additionally, we utilize the isotemporal substitution model (ISM) to examine how replacing brief durations of leisure-time SB with light physical activity (LPA), moderate physical activity (MPA), vigorous physical activity (VPA), and sleep might influence the risk of stroke.</p>
Methods: This investigation tracked 478,198 participants from the UK Biobank. Data regarding individual leisure-time SB and PA were collected through a standardized questionnaire. A Cox proportional hazards model, alongside an isotemporal substitution model (ISM), was utilized.</p>
Results: We identified 10,003 cases of incident stroke over 12.7 years. When compared to participants who engaged in leisure-time SB for less than 4 hours per day, the hazard ratios (HRs) for stroke incidence increased with more prolonged leisure-time SB: HRs were 1.06 (95% CI: 1.01 to 1.11) for 4-6 h/d, 1.16 (95% CI: 1.10 to 1.23) for 6-8 h/d, and 1.24 (95% CI: 1.15 to 1.33) for over 8 h/d. According to the ISM analysis, substituting leisure-time SB with various forms of PA could markedly reduce stroke risk. For individuals sleeping ≤8h/d, replacing one hour of leisure-time SB with an equivalent duration of LPA, VPA, or sleep corresponded to a 3.0%, 7.0%, and 22.0% decrease in stroke risk, respectively. Meanwhile, for those already sleeping more than 8h/d, substituting one hour of leisure-time SB with an equivalent duration of LPA or VPA resulted in a notable decrease in the risk of stroke by 6.0% and 18.0%, respectively.</p>
Conclusion: The findings demonstrate that leisure-time SB and unhealthy sleep durations are confirmed risk factors for stroke. For individuals sleeping 8 hours or less per day, and for those who sleep more than 8 hours, substituting SB with an adequate amount of sleep or engaging in VPA, respectively, emerges as an effective strategy for reducing stroke risk.</p>
8 Authors
- Xiao-Fang Dong
- Qiang Zhang
- Jia-Ning Wei
- Qian-Yu Zhou
- Fan-Jia-Yi Yang
- Yan-Jin Liu
- Yu-Sheng Li
- Chang-Qing Sun
1 Application
| Application ID | Title |
|---|---|
| 71051 | Integration of traditional risk factors and biomarkers from UK Biobank and other omics data to diagnose, predict, understand, and inform treatment of complex traits or diseases. |
Enabling scientific discoveries that improve human health