| Title: | Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults. |
| Journal: | Diabetes Care |
| Published: | 10 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39388339/ |
| DOI: | https://doi.org/10.2337/dc24-1208 |
Publication 13248
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Abstract
OBJECTIVE: To prospectively examine the association between device-measured sleep regularity and incidence of type 2 diabetes (T2D) in a population-based sample of adults. We also examined if meeting sleep duration recommendations attenuated or eliminated the effects of irregular sleep on T2D.</p>
RESEARCH DESIGN AND METHODS: We conducted a prospective cohort study of adults aged 40-79 years participating in the UK Biobank accelerometer substudy. Participants wore wrist-attached accelerometers for a duration of 7 days, which was used to compute the Sleep Regularity Index (SRI). Participants were categorized as irregular (SRI <71.6), moderately irregular (SRI between 71.6 and 87.3), and regular (SRI >87.3) sleepers. T2D diagnosis was obtained through self-reports and health records.</p>
RESULTS: We analyzed data from 73,630 individuals observed for 8 years, without a history of T2D and without an event in the first year of follow-up. Compared with regular sleepers, irregular (hazard ratio [HR] 1.38; 95% CI 1.20-1.59) and moderately irregular sleepers (HR 1.35; 95% CI 1.19-1.53) were at higher risk of T2D incidence. Dose-response analyses treating SRI as a continuous measure showed higher T2D incidence with SRI scores <80. Meeting current sleep duration recommendations did not counteract the adverse effects of irregular (HR 1.35; 95% CI 1.09-1.66) or moderately irregular (HR 1.29; 95% CI 1.08-1.54) sleep on T2D incidence.</p>
CONCLUSIONS: Moderate and high sleep irregularity were deleteriously associated with T2D risk, even in participants who slept ≥7 h per night. Future sleep interventions will need to pay more attention to consistency in bedtimes and wake-up times, in addition to sleep duration and quality.</p>
12 Keywords
- Accelerometry
- Adult
- Aged
- Diabetes Mellitus, Type 2
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- Sleep
- Sleep Wake Disorders
7 Authors
- Jean-Philippe Chaput
- Raaj Kishore Biswas
- Matthew Ahmadi
- Peter A Cistulli
- Angelo Sabag
- Marie-Pierre St-Onge
- Emmanuel Stamatakis
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