| Title: | The relationship between serum lipid with sarcopenia: Results from the NHANES 2011-2018 and bidirectional Mendelian randomization study |
| Journal: | Experimental Gerontology |
| Published: | 28 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39214262/ |
| DOI: | https://doi.org/10.1016/j.exger.2024.112560 |
Publication 13170
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: The relationship between serum lipids and sarcopenia remains unclear due to conflicting results in previous studies.</p>
OBJECTIVE: To explore the associations and potential causality between serum lipids, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC), and sarcopenia.</p>
METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) were analysed using multivariable regression and restricted cubic splines (RCSs) to assess the associations between serum lipids and sarcopenia. Bidirectional Mendelian randomization (MR) was employed to investigate the causal relationships with sarcopenia-related traits such as appendicular lean mass (ALM), hand grip strength, and usual walking pace.</p>
RESULTS: Serum HDL-C and TG levels were inversely associated with ALMBMI, with each 1-unit increase linked to a 0.13 % and 1.32 % decrease, respectively. Elevated TG, but not HDL-C, LDL-C, or TC levels, was significantly associated with an increased risk of sarcopenia (P for trend = 0.001). RCS analysis revealed a log-shaped dose-response relationship between TG and sarcopenia risk (P overall <0.001, P non-linear <0.001), with a cutoff value of 92.75 mg/dL. Genetically predicted HDL-C, LDL-C, and TG were associated with ALM. Conversely, ALM showed an inverse causal relationship with all four serum lipids. Additionally, genetically predicted usual walking pace influenced HDL-C and TG levels (P < 0.001).</p>
CONCLUSION: The study reveals a nonlinear association between TG levels and sarcopenia risk, and a bidirectional association between lipid profiles and muscle mass, underscoring the need for further research to elucidate these mechanisms.</p>
15 Keywords
- Adult
- Aged
- Cholesterol, HDL
- Cholesterol, LDL
- Female
- Hand Strength
- Humans
- Lipids
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Nutrition Surveys
- Risk Factors
- Sarcopenia
- Triglycerides
8 Authors
- Huanhuan Huang
- Xinyu Yu
- Siqi Jiang
- Chunni Wang
- Zhiyu Chen
- Deqing Chen
- Xuesen Yang
- Qinghua Zhao
Enabling scientific discoveries that improve human health