| Title: | Accelerometer-measured intensity-specific physical activity, genetic predisposition, and the risk of venous thromboembolism: A cohort study |
| Journal: | European Journal of Preventive Cardiology |
| Published: | 19 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39158115/ |
| DOI: | https://doi.org/10.1093/eurjpc/zwae273 |
Publication 13149
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Abstract
OBJECTIVES: The association between physical activity and venous thromboembolism (VTE) remains unclear. Therefore, we investigated the prospective dose-response associations between accelerometer-measured intensity-specific physical activity and new-onset VTE, accounting for genetic risk.</p>
METHODS: In total, 85,116 participants from the UK Biobank were included. Incident VTE was identified via linked hospital records and death registries. A weighted polygenic risk score (PRS) was used to quantifying genetic risk for VTE, with higher values indicating a high genetic risk. Cox proportional hazard models were used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of the associations.</p>
RESULTS: Overall, 1,182 incident VTE cases were documented during a median follow-up of 6.18 years. In the overall study population, the participants in the highest quartiles of total volume of physical activity (0.60 [0.45, 0.79]), moderate-to-vigorous-intensity physical activity (0.66 [0.51, 0.86]), and light-intensity physical activity (0.66 [0.51, 0.85]) had lower adjusted HRs (95% CIs) for VTE than those of participants in the lowest quartiles. Both total volume of physical activity and light-intensity physical activity were negatively associated with VTE risk in participants with low, intermediate, and high PRS. However, moderate-to-vigorous-intensity physical activity was only protective against VTE in participants with low and intermediate PRS, with a significant interaction (P for interaction=0.02).</p>
CONCLUSION: Higher levels of physical activity of any intensity were associated with a lower risk of new-onset VTE. However, the negative association between moderate-to-vigorous-intensity physical activity and new-onset VTE was significant only in participants with low and intermediate genetic predispositions to VTE.</p>
8 Authors
- Rui Ye
- Honghao Yang
- Shiwen Li
- Chao Ji
- Liangkai Chen
- Yuhong Zhao
- Li Zhao
- Yang Xia
1 Application
| Application ID | Title |
|---|---|
| 63454 | Understand the relationship between diet, lifestyle and gene-environment interactions and healthy aging |
Enabling scientific discoveries that improve human health