| Title: | Association between frailty and main work during the LIFE: A cross-sectional analysis of the UK Biobank |
| Journal: | Experimental Gerontology |
| Published: | 16 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39153414/ |
| DOI: | https://doi.org/10.1016/j.exger.2024.112548 |
Publication 13122
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Abstract
BACKGROUND: The role of main work during the life course in predicting frailty, a typical geriatric syndrome, is still largely unknown. Therefore, with this research, we aimed to investigate the potential association between the main work done during the life with frailty and pre-frailty among participants 60 years and older of the UK Biobank study.</p>
METHODS: Frailty and pre-frailty presence were ascertained using a model including 5 indicators (weakness, slowness, weight loss, low physical activity, and exhaustion); the main employment status was ascertained using self-reported information. The association between frailty and main work was explored using an ordinal logistic regression model and reported as odds ratios (ORs) with their 95 % confidence intervals (CIs).</p>
RESULTS: The final sample comprised a total of 50,447 individuals (mean age: 64.2 years, females: 50.2 %). Individuals with higher qualifications had a reduced risk of frailty (OR = 0.881, 95%CI = 0.83-0.95, p-value<0.001 for pre-frail and OR = 0.681, 95%CI = 0.63-0.73, p-value<0.001 for frail) compared to those with lower qualifications. Moreover, active participation in the workforce, compared to being inactive, emerged as a protective factor from frailty (OR = 0.753, 95%CI = 0.70-0.81, p-value<0.001). The categories of Associate Professional and Technical Occupations exhibited protective effects against both pre-frailty and frailty. Similarly, occupations categorized as Professional and Management demonstrated protective effects against pre-frailty and frailty when compared to Elementary Occupations. Additionally, engagement in Trades and Services occupations, as opposed to Elementary Occupations, appeared to be protective against frailty.</p>
CONCLUSIONS: In this large cross-sectional investigation based on the data of the UK Biobank we found that work during lifetime could be an important factor in determining frailty later in life.</p>
16 Keywords
- Aged
- Biological Specimen Banks
- Cross-Sectional Studies
- Employment
- Exercise
- Female
- Frail Elderly
- Frailty
- Geriatric Assessment
- Humans
- Logistic Models
- Male
- Middle Aged
- Risk Factors
- UK Biobank
- United Kingdom
5 Authors
- Nicola Veronese
- Laura Maniscalco
- Domenica Matranga
- Ligia J Dominguez
- Mario Barbagallo
1 Application
| Application ID | Title |
|---|---|
| 82722 | Impact of genotype and environmental factors in the relationship between frailty and chronic-degenerative diseases in older people |
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