| Title: | Multifaceted association of overweight and metabolically unhealthy with the risk of Barrett's esophagus in the UK Biobank cohort |
| Journal: | Scientific Reports |
| Published: | 30 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39215131/ |
| DOI: | https://doi.org/10.1038/s41598-024-71057-3 |
Publication 13051
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Abstract
The association of overweight/obesity and metabolically unhealthy (MU) with the risk of developing Barrett's esophagus (BE) remains uncertain. We evaluated whether MU and overweight/obesity are associated with increased BE incidence and whether they have a synergistic impact on BE development. We analyzed the body mass index (BMI) and metabolic indicators at baseline of 402,510 individuals from the UK Biobank with no history of BE. Overweight/obesity and MU were defined as BMI ≥ 25.0 kg/m2 and presence of ≥ 1 MU indicators, respectively. Accordingly, the participants were categorized into four groups: (1) metabolically healthy non-overweight/obesity (MHNO), (2) metabolically unhealthy non-overweight/obesity (MUNO), (3) metabolically healthy overweight/obesity (MHO), and (4) metabolically unhealthy overweight/obesity (MUO). During a median follow-up of 13.5 years, 6195 (1.5%) individuals were newly diagnosed with BE. Among them, 39,281 (9.8%), 92,000 (22.9%), 25,297 (6.3%), and 245,932 (61.1%) individuals were classified as MHNO, MUNO, MHO, and MUO, respectively. In Cox regression analyses, both MU and overweight/obesity were independently associated with BE incidence. Moreover, BE incidence was significantly higher in the MUNO, MHO, and MUO groups, compared to the MHNO group. MU and overweight/obesity are independent risk factors for BE and have a synergistic effect on BE development.</p>
16 Keywords
- Adult
- Aged
- Barrett Esophagus
- Biological Specimen Banks
- Body Mass Index
- Cohort Studies
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Obesity
- Overweight
- Risk Factors
- UK Biobank
- United Kingdom
10 Authors
- Da Hyun Jung
- Yeon Ji Kim
- Hee Byung Koh
- Nak-Hoon Son
- Jung Tak Park
- Seung Hyeok Han
- Tae-Hyun Yoo
- Shin-Wook Kang
- Cheal Wung Huh
- Hae-Ryong Yun
1 Application
| Application ID | Title |
|---|---|
| 73873 | The study of biological, behavioral, ethnic , environmental, and genetic factors affecting the incidence, progression of CKD, and the risk of developing adverse outcomes in patients with CKD |
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