| Title: | Sex disparity in the association between metabolic-anthropometric phenotypes and risk of obesity-related cancer: a prospective cohort study |
| Journal: | BMC Medicine |
| Published: | 2 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39218868/ |
| DOI: | https://doi.org/10.1186/s12916-024-03592-9 |
Publication 13036
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Abstract
BackgroundSex disparity between metabolic-obesity (defined by body mass index, BMI) phenotypes and obesity-related cancer (ORC) remains unknown. Considering BMI reflecting overall obesity but not fat distribution, we aimed to systematically assess the association of our newly proposed metabolic-anthropometric phenotypes with risk of overall and site-specific ORC by sex.MethodsA total of 141,579 men (mean age: 56.37 years, mean follow-up time: 12.04 years) and 131,047 women (mean age: 56.22 years, mean follow up time: 11.82 years) from the UK Biobank was included, and designated as metabolic-anthropometric phenotypes based on metabolic status (metabolically healthy/unhealthy), BMI (non-obesity/obesity) and body shape (pear/slim/apple/wide). The sex-specific association of different phenotypes with overall and site-specific ORC was assessed by hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression models.ResultsWe found metabolically unhealthy and/or obesity phenotypes conveyed a higher risk in men than in women for overall ORC and colorectal cancer compared with metabolically healthy non-obesity phenotype (Pinteraction < 0.05). Of note, metabolically healthy obesity phenotype contributed to increased risks of most ORC in men (HRs: 1.58 ~ 2.91), but only correlated with higher risks of endometrial (HR = 1.89, 95% CI: 1.54-2.32) and postmenopausal breast cancers (HR = 1.17, 95% CI: 1.05-1.31) in women. Similarly, even under metabolically healthy, men carrying apple and wide shapes phenotypes (metabolically healthy apple/wide and metabolically healthy non-obesity apple/wide) suffered an increased risk of ORC (mainly colorectal, liver, gastric cardia, and renal cancers, HRs: 1.20 ~ 3.81) in comparison with pear shape or non-obesity pear shape.ConclusionsThere was a significant sex disparity between metabolic-anthropometric phenotypes and ORC risk. We advised future ORC prevention and control worth taking body shape and sex disparity into account.</p>
15 Keywords
- Adult
- Aged
- Anthropometry
- Body Mass Index
- Female
- Humans
- Male
- Middle Aged
- Neoplasms
- Obesity
- Phenotype
- Prospective Studies
- Risk Factors
- Sex Factors
- United Kingdom
10 Authors
- Jianxiao Gong
- Fubin Liu
- Yu Peng
- Peng Wang
- Changyu Si
- Xixuan Wang
- Huijun Zhou
- Jiale Gu
- Ailing Qin
- Fangfang Song
1 Application
| Application ID | Title |
|---|---|
| 76092 | Uncovering the causal mechanism between environmental exposure and cancer by integrating exposome, genomic, clinical phenomic and radiomic data |
Enabling scientific discoveries that improve human health