| Title: | Unraveling the influence of childhood emotional support on adult aging: Insights from the UK Biobank |
| Journal: | Archives of Gerontology and Geriatrics |
| Published: | 12 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39151235/ |
| DOI: | https://doi.org/10.1016/j.archger.2024.105600 |
Publication 13004
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Abstract
BACKGROUND: Exploring the association between Childhood Emotional Support (CES) and the mechanisms of aging is pivotal for understanding its potential to lessen the incidence of age-related pathologies and promote a milieu for healthy aging.</p>
METHODS: Utilizing data from the UK Biobank comprising nearly 160,000 individuals, comprehensive analyses were conducted to explore associations between CES levels and age-related diseases, biological age and aging hallmarks. Cox proportional hazards regression models were used to investigate the relationship between CES and the risk of hospitalization for age-related diseases. Linear regression models were employed to explore the associations between CES and the frailty index (FI), Klemera-Doubal method (KDM) biological age acceleration, homeostatic dysregulation (HD), C-reactive protein (CRP), white blood cell (WBC) count, and telomere length.</p>
RESULTS: The analyses revealed a significant association between higher CES levels and a decreased risk of hospitalization for age-related diseases in later life. After adjustments for covariates, the hazard ratio for age-related diseases was 0.87 (95 % confidence interval, 0.83-0.91, p < 0.001) in those with the highest CES level compared to those with the lowest CES level. Participants with the highest CES level exhibited lower FI scores (coefficient = -0.033, p < 0.001), reduced CRP level (coefficient = -0.097, p < 0.05) and lower WBC counts (coefficient = -0.034, p < 0.05). Stratified analyses based on genetic susceptibility further elucidated the protective role of CES against age-related diseases.</p>
CONCLUSION: These findings underscore the potential of early interventions targeting CES to promote healthy aging and alleviating the burden of age-related diseases.</p>
6 Authors
- Shibo Zhang
- Tianshu Han
- Ruiming Yang
- Yuxin Song
- Wenbo Jiang
- Zhiliang Tian
1 Application
| Application ID | Title |
|---|---|
| 103547 | The health impacts of lifestyle and environmental factors exposed at different life stages on aging and non-communicable chronic diseases |
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