| Title: | Association between temperatures and type 2 diabetes: A prospective study in UK Biobank |
| Journal: | Diabetes Research and Clinical Practice |
| Published: | 10 Aug 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39128563/ |
| DOI: | https://doi.org/10.1016/j.diabres.2024.111817 |
Publication 12993
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Abstract
OBJECTIVE: This study aims to prospectively examine the association between temperatures and the occurrence of type 2 diabetes (T2D).</p>
METHODS: We used the CPH models to analyze 103,215 non-diabetic participants in the UK Biobank cohort who answered questions about workplace temperature, to evaluate the survival relationship, and the interaction effects of working environmental temperature and T2D-related genetic risk scores (GRS) on the occurrence of T2D. The occurrence of T2D was assessed by hospital inpatient records. The weighted T2D-related GRS were calculated.</p>
RESULTS: During 1,355,200.6 person-years follow-up, a total of 2436 participants were documented as having diagnosed T2D. After adjustment, compared to the comfortable group, the participants working in non-comfortable environmental temperature had greater risk of T2D (HR: 1.27, 95 %CI: 1.04 to 1.55, for cold; HR: 1.32, 95 %CI: 1.17 to 1.48 for hot; HR: 1.51, 95 %CI: 1.38 to 1.65 for alternate). Similarly, individuals exposed to different levels of genetic risk scores in alternating hot and cold work environments had a higher risk of developing type 2 diabetes.</p>
CONCLUSIONS: This study found working in single non-comfortable environmental temperatures was associated with greater risk of T2D occurrence, and exposure to alternating environmental temperatures had the highest risk of range and severity.</p>
15 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cold Temperature
- Diabetes Mellitus, Type 2
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Temperature
- UK Biobank
- United Kingdom
7 Authors
- ShengYuan Wang
- YaTing Lei
- XiaoLi Wang
- Kun Ma
- Cheng Wang
- ChangHao Sun
- TianShu Han
1 Application
| Application ID | Title |
|---|---|
| 90232 | Association of risk factors in terms of diet, lifestyle, genetic susceptibility, metabolic disorder and treatment with the comorbidity of diabetes with cancer. |
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