| Title: | Non-Modifiable Factors as Moderators of the Relationship Between Physical Activity and Brain Volume: A Cross-Sectional UK Biobank Study. |
| Journal: | Journal of Alzheimer's Disease |
| Published: | 1 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35754269/ |
| DOI: | https://doi.org/10.3233/jad-220114 |
| URL: | https://www.medrxiv.org/content/medrxiv/early/2022/01/02/2022.01.01.22268616.full.pdf |
| Citations: | 2 (2 in last 2 years) as of 8 Aug 2024 |
Publication 12869
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Abstract
BACKGROUND: Previous research suggests physical activity attenuates grey and white matter loss; however, there appears to be individual variability in this effect. Understanding factors that can influence the relationship between physical activity and brain volume may enable prediction of individual response.</p>
OBJECTIVE: The current study examined the relationship between objectively-measured physical activity and brain volume; and whether this relationship is moderated by age, sex, or a priori candidate genetic factors, brain-derived neurotrophic factor (BDNF) Val66Met, or apolipoprotein (APOE) ɛ4 allele carriage.</p>
METHODS: Data from 10,083 men and women (50 years and over) of the UK Biobank were used to examine the study objectives. All participants underwent a magnetic resonance imaging scan to quantify grey and white matter volumes, physical activity monitoring via actigraphy, and genotyping.</p>
RESULTS: Physical activity was associated with total grey matter volume, total white matter volume, and right hippocampal volume. Only males had an association between higher physical activity levels and greater cortical grey matter volume, total grey matter volume, and right hippocampal volume. Age moderated the relationship between physical activity and white matter volume.</p>
CONCLUSION: Our results indicate that in males, but not females, an association exists between objectively-measured physical activity and grey matter volume. Age may also play a role in impacting the relationship between physical activity and brain volume. Future research should evaluate longitudinal brain volumetrics to better understand the nature of age and sex-effects on the physical activity and brain volume relationship.</p>
12 Keywords
- Biological Specimen Banks
- Brain
- Cross-Sectional Studies
- Exercise
- Female
- Gray Matter
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- United Kingdom
- White Matter
7 Authors
- Belinda M Brown
- Jaisalmer de Frutos Lucas
- Tenielle Porter
- Natalie Frost
- Michael Vacher
- Jeremiah J Peiffer
- Simon M Laws
1 Application
| Application ID | Title |
|---|---|
| 45567 | Tailoring exercise to maintain cognitive health: Is benefit moderated by genetics and gender? |
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