| Title: | Habitual Iron Supplementation Associated with Elevated Risk of Chronic Kidney Disease in Individuals with Antihypertensive Medication |
| Journal: | Nutrients |
| Published: | 20 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39064798/ |
| DOI: | https://doi.org/10.3390/nu16142355 |
Publication 12796
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Abstract
The aim of this study was to examine the effects of habitual iron supplementation on the risk of CKD in individuals with different hypertensive statuses and antihypertension treatment statuses. We included a total of 427,939 participants in the UK Biobank study, who were free of CKD and with complete data on blood pressure at baseline. Cox proportional hazards regression models were used to examine the adjusted hazard ratios of habitual iron supplementation for CKD risk. After multivariable adjustment, habitual iron supplementation was found to be associated with a significantly higher risk of incident CKD in hypertensive participants (HR 1.12, 95% CI 1.02 to 1.22), particularly in those using antihypertensive medication (HR 1.21, 95% CI 1.08 to 1.35). In contrast, there was no significant association either in normotensive participants (HR 1.06, 95% CI 0.94 to 1.20) or in hypertensive participants without antihypertensive medication (HR 1.02, 95% CI 0.90 to 1.17). Consistently, significant multiplicative and additive interactions were observed between habitual iron supplementation and antihypertensive medication on the risk of incident CKD (p all interaction < 0.05). In conclusion, habitual iron supplementation was related to a higher risk of incident CKD among hypertensive patients, the association might be driven by the use of antihypertensive medication.</p>
16 Keywords
- Adult
- Aged
- Antihypertensive Agents
- Blood Pressure
- Dietary Supplements
- Female
- Humans
- Hypertension
- Incidence
- Iron
- Male
- Middle Aged
- Proportional Hazards Models
- Renal Insufficiency, Chronic
- Risk Factors
- United Kingdom
10 Authors
- Xiaoyan Ma
- Jiali Lv
- Shuai Zhang
- Xiaofeng Zhang
- Xia Lin
- Shengxu Li
- Lin Yang
- Fuzhong Xue
- Fan Yi
- Tao Zhang
1 Application
| Application ID | Title |
|---|---|
| 143463 | Integrating phenotypic and multi-omics data to comprehensively explore the potential molecular mechanisms of the interaction between metabolites and lifestyle behaviors in chronic kidney disease |
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