| Title: | MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease |
| Journal: | Obesity |
| Published: | 25 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39051177/ |
| DOI: | https://doi.org/10.1002/oby.24108 |
Publication 12777
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Abstract
OBJECTIVE: This study aimed to assess the fatty acid (FA) composition of abdominal subcutaneous and visceral adipose tissue (ASAT and VAT, respectively) in the UK Biobank imaging cohort (N = 33,823) using magnetic resonance imaging (MRI).</p>
METHODS: We measured the fractions of saturated, monounsaturated, and polyunsaturated FA (fSFA, fMUFA, and fPUFA, respectively) in ASAT and VAT from multiecho MRI scans. We selected a subcohort of participants who followed a vegan and an omnivore diet (N = 36) to validate the effect of diet on adipose tissue. In the wider imaging cohort, we examined the relationships between adipose tissue FA composition and various traits related to disease and body size.</p>
RESULTS: We measured adipose tissue FA composition for over 33,000 participants, revealing higher fSFA and fPUFA and lower fMUFA in VAT (p < 0.00016). fMUFA and fPUFA were higher in ASAT and lower in VAT for women (p < 0.00016). Vegan participants exhibited lower fSFA in both ASAT and VAT (p < 0.00016). VAT fSFA and fMUFA showed significant associations with disease, as well as anthropometric variables.</p>
CONCLUSIONS: This extensive analysis revealed the relationships between adipose tissue FA composition and a range of factors in a diverse population, highlighting the importance of studying body adipose tissue beyond its quantity.</p>
5 Authors
- Marjola Thanaj
- Nicolas Basty
- Brandon Whitcher
- Jimmy D. Bell
- E. Louise Thomas
1 Application
| Application ID | Title |
|---|---|
| 44584 | Enriched Image Based Phenotypes for Health Exploration and Discovery |
Enabling scientific discoveries that improve human health