| Title: | Associations of childhood and adulthood body size, and child-to-adult body size change with adult telomere length |
| Journal: | Diabetes Obesity and Metabolism |
| Published: | 31 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39086030/ |
| DOI: | https://doi.org/10.1111/dom.15825 |
Publication 12743
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Abstract
AIM: To comprehensively examine the associations of childhood and adulthood body size, and child-to-adult body size change with adult leucocyte telomere length (LTL).</p>
METHODS: We included 453 602 participants from the UK Biobank. Childhood body size at the age of 10 years was collected through a questionnaire. Adulthood body size was assessed using body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), fat mass index (FMI), and fat-free mass index (FFMI).</p>
RESULTS: Individuals with plumper body size in childhood exhibited shorter LTL in adulthood (-0.0086 [-0.0017, -0.0004]). Adulthood BMI (-0.0286 [-0.0315, -0.0258]), WC (-0.0271 [-0.0303, -0.0238]), WHR (-0.0269 [-0.0308, -0.0230]) and FMI (-0.0396 [-0.0438, -0.0351]) were negatively associated with LTL, whereas FFMI (0.0095 [0.0039, 0.0152]) was positively associated with LTL. Compared to individuals consistently having an average/normal weight in both childhood and adulthood, those who maintained or developed overweight/obesity from childhood to adulthood had a shorter adult LTL, regardless of childhood body size. Notably, the LTL shortening effect was not observed in individuals with plumper body size in childhood but normal weight in adulthood.</p>
CONCLUSIONS: Childhood and adulthood obesity are both associated with LTL shortening in adulthood. Transitioning to or maintaining overweight/obese status from childhood to adulthood is associated with shorter adult LTL, whereas this effect can be reversed if plumper children become normal weight.</p>
15 Keywords
- Adult
- Aged
- Body Mass Index
- Body Size
- Child
- Female
- Humans
- Leukocytes
- Male
- Middle Aged
- Telomere
- Telomere Shortening
- United Kingdom
- Waist Circumference
- Waist-Hip Ratio
12 Authors
- Qing Liu
- Gaojie Fan
- Jianing Bi
- Qing Fang
- Fei Luo
- Xiaofeng Huang
- Heng Li
- Binghai Liu
- Lianyan Yan
- Wenwen Guo
- Youjie Wang
- Lulu Song
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
Enabling scientific discoveries that improve human health