| Title: | Association of Kidney Function with Risk of Incident Dementia: A Prospective Cohort Study of 275,167 UK Biobank Participants. |
| Journal: | Journal of Alzheimer's Disease |
| Published: | 1 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36245378/ |
| DOI: | https://doi.org/10.3233/jad-220609 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 12632
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Abstract
BACKGROUND: Previous studies have reported inconsistent associations between chronic kidney disease (CKD) and dementia.</p>
OBJECTIVE: To evaluate whether CKD is a risk factor for dementia and compare the performance of different measures of calculating estimated glomerular filtration rate (eGFR).</p>
METHODS: 275,167 participants from UK Biobank were included and eGFR at baseline was calculated using serum creatinine (eGFRcr), cystatin C (eGFRcys), and creatinine-cystatin C equations (eGFRcr-cys). Restricted cubic splines and Cox regression models were performed to assess the relationship of eGFR with all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD).</p>
RESULTS: We observed a U-shaped relationship between each eGFR and risk of all-cause dementia and VaD, with eGFRcys and eGFRcr-cys showing a closer linkage (peGFRcys <0.0001, peGFRcrhboxcys<0.0001 and peGFRcr = 0.0001). Lower and supranormal eGFR were related to increased risk of all-cause dementia. Compared to the reference category of 90-104 ml/min/1.73 m2, adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of all-cause dementia for eGFRcr-cys 30-59, <30, and ≥105 ml/min/1.73 m2 were 1.26 (95% CI [1.05-1.50], p = 0.012), 2.62 (95% CI [1.54-4.47], p < 0.001), and 1.41 (95% CI [1.17-1.70], p < 0.001). No statistically significant association was observed between eGFR with risk of AD.</p>
CONCLUSION: This prospective study identified impaired kidney function as a critical risk factor for dementia and noted the application of cystatin C strengthened the relationship between CKD and dementia, underlining the significant value of preserving kidney function to reduce the risk of dementia and considering cystatin C measurement as part of clinical practice.</p>
11 Keywords
- Biological Specimen Banks
- Creatinine
- Cystatin C
- Dementia
- Glomerular Filtration Rate
- Humans
- Kidney
- Prospective Studies
- Renal Insufficiency, Chronic
- Risk Factors
- United Kingdom
9 Authors
- Xin-Rui Wu
- Kai-Min Wu
- Yue-Ting Deng
- Shu-Yi Huang
- Liu Yang
- Qiang Dong
- Jian-Feng Feng
- Wei Cheng
- Jin-Tai Yu
1 Application
| Application ID | Title |
|---|---|
| 19542 | Identifying multi-level biomarkers and disease mechanisms for major mental disorders |
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