| Title: | Genetic Risk and Chronic Obstructive Pulmonary Disease Independently Predict the Risk of Incident Severe COVID-19 |
| Journal: | Annals of the American Thoracic Society |
| Published: | 1 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/34242153/ |
| DOI: | https://doi.org/10.1513/annalsats.202102-171oc |
| Citations: | 12 (7 in last 2 years) as of 8 Aug 2024 |
Publication 12631
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Abstract
Rationale: Both genetic variants and chronic obstructive pulmonary disease (COPD) contribute to the risk of incident severe coronavirus disease (COVID-19). Whether genetic risk of incident severe COVID-19 is the same regardless of preexisting COPD is unknown. Objectives: In this study, we aimed to investigate the potential interaction between genetic risk and COPD in relation to severe COVID-19. Methods: We constructed a polygenic risk score for severe COVID-19 by using 112 single-nucleotide polymorphisms in 430,582 participants from the UK Biobank study. We examined the associations of genetic risk and COPD with severe COVID-19 by using logistic regression models. Results: Of 430,582 participants, 712 developed severe COVID-19 as of February 22, 2021, of whom 19.8% had preexisting COPD. Compared with participants at low genetic risk, those at intermediate genetic risk (odds ratio [OR], 1.34; 95% confidence interval [CI], 1.09-1.66) and high genetic risk (OR, 1.50; 95% CI, 1.18-1.92) had higher risk of severe COVID-19 (P for trend = 0.001), and the association was independent of COPD (P for interaction = 0.76). COPD was associated with a higher risk of incident severe COVID-19 (OR, 1.37; 95% CI, 1.12-1.67; P = 0.002). Participants at high genetic risk and with COPD had a higher risk of severe COVID-19 (OR, 2.05; 95% CI, 1.35-3.04; P < 0.001) than those at low genetic risk and without COPD. Conclusions: The polygenic risk score, which combines multiple risk alleles, can be effectively used in screening for high-risk populations of severe COVID-19. High genetic risk correlates with a higher risk of severe COVID-19, regardless of preexisting COPD.</p>
6 Keywords
- COVID-19
- Humans
- Polymorphism, Single Nucleotide
- Pulmonary Disease, Chronic Obstructive
- Risk Factors
- SARS-CoV-2
14 Authors
- Qing-Mei Huang
- Pei-Dong Zhang
- Zhi-Hao Li
- Jian-Meng Zhou
- Dan Liu
- Xi-Ru Zhang
- Wen-Fang Zhong
- Yu-Jie Zhang
- Dong Shen
- Fen Liang
- Wei-Qi Song
- Shi-Gui Yang
- Wei-Jie Guan
- Chen Mao
1 Application
| Application ID | Title |
|---|---|
| 43795 | Explore the associations between different exposures and health outcomes. |
Enabling scientific discoveries that improve human health