| Title: | Weight loss in a cardiovascular trial population identifies people at future risk of dementia |
| Journal: | Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring |
| Published: | 1 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36092692/ |
| DOI: | https://doi.org/10.1002/dad2.12352 |
| URL: | https://www.pure.ed.ac.uk/ws/files/297195111/DAD2_14_e12352.pdf |
Publication 12625
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Abstract
Introduction: Populations at increased risk of dementia need to be identified for well-powered trials of preventive interventions. Weight loss, which often occurs in pre-clinical dementia, could identify a population at sufficiently high dementia risk.</p>
Methods: In 12,975 survivors in the Heart Protection Study statin trial of people with, or at high risk of, cardiovascular disease, the association of weight change over 5 years during the trial with post-trial dementia recorded in electronic hospital admission and death records (n = 784) was assessed, after adjustment for age, sex, treatment allocation, and deprivation measures.</p>
Results: Among the 60% without substantial weight gain (≤2 kg weight gain), each 1 kg weight loss was associated with a risk ratio for dementia of 1.04 (95% confidence interval, 1.02-1.07). Weight loss ≥4 kg and cognitive function below the mean identified participants aged ≥67 years with a 13% 10-year dementia risk.</p>
Discussion: The combination of weight loss and high vascular risk identified individuals at high risk of dementia who could be recruited to dementia prevention trials.</p>
13 Authors
- Pieter van der Veere
- Imen Hammami
- Georgina Buck
- Melanie Greenland
- Alison Offer
- Michelle Nunn
- William Whiteley
- Richard Bulbulia
- Rory Collins
- Jane Armitage
- Marion Mafham
- Sarah Parish
- the Heart Protection Study Collaborative Group
1 Application
| Application ID | Title |
|---|---|
| 8835 | Investigation of the causal association between vascular risk factors, cognitive function and dementia using genetic instruments |
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