| Title: | A multi-environments-gene interaction study of anxiety, depression and self-harm in the UK Biobank cohort |
| Journal: | Journal of Psychiatric Research |
| Published: | 5 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35026594/ |
| DOI: | https://doi.org/10.1016/j.jpsychires.2022.01.009 |
| Citations: | 10 (7 in last 2 years) as of 8 Aug 2024 |
Publication 12622
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Abstract
The effects of gene-by-environment (G×E) interactions on complex diseases are significant, especially the superimposed effects of multiple environmental factors. However, research on the multi-environments-gene interactions of anxiety, depression, and self-harm is still limited. This study included white individuals (N = 66,041-74,482) from the UK Biobank. We fitted all environmental factors to a single environmental score (ES), and the estimated ES was used to calculate the multiplicative interaction effects between ES and genome-wide SNPs. Heritability was stratified by minor allele frequency (MAF) and linkage disequilibrium (LD). Our research found 10 loci with significant interaction effects, such as rs114830993 (PRICKLE2, P = 2.30 × 10-8), rs151323364 (ASTN2, P = 2.71 × 10-10) and rs536631793 (SYN3, P = 4.09 × 10-8). In addition, we found that G×E heritability has a significant contribution to the depression of Patient Health Questionnaire-9 (PHQ-9) scores (h2G×E (female) = 6.1%, h2G×E (male) = 8.7%). Our research supported the important influence of multi-environments-gene interactions on anxiety, depression, and self-harm and provided clues for the prevention and etiological research of them.</p>
9 Keywords
- Anxiety
- Biological Specimen Banks
- Female
- Gene-Environment Interaction
- Genome-Wide Association Study
- Humans
- Male
- Self-Injurious Behavior
- United Kingdom
12 Authors
- Chun'e Li
- Xiao Liang
- Shiqiang Cheng
- Yan Wen
- Chuyu Pan
- Huijie Zhang
- Yujing Chen
- Jingxi Zhang
- Zhen Zhang
- Xuena Yang
- Peilin Meng
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
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