| Title: | Evaluating the interactive effects of dietary habits and human gut microbiome on the risks of depression and anxiety |
| Journal: | Psychological Medicine |
| Published: | 25 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35074039/ |
| DOI: | https://doi.org/10.1017/s0033291721005092 |
| Citations: | 8 (5 in last 2 years) as of 8 Aug 2024 |
Publication 12586
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Abstract
BACKGROUND: Gut microbiome and dietary patterns have been suggested to be associated with depression/anxiety. However, limited effort has been made to explore the effects of possible interactions between diet and microbiome on the risks of depression and anxiety.</p>
METHODS: Using the latest genome-wide association studies findings in gut microbiome and dietary habits, polygenic risk scores (PRSs) analysis of gut microbiome and dietary habits was conducted in the UK Biobank cohort. Logistic/linear regression models were applied for evaluating the associations for gut microbiome-PRS, dietary habits-PRS, and their interactions with depression/anxiety status and Patient Health Questionnaire (PHQ-9)/Generalized Anxiety Disorder-7 (GAD-7) score by R software.</p>
RESULTS: We observed 51 common diet-gut microbiome interactions shared by both PHQ score and depression status, such as overall beef intake × genus Sporobacter [hurdle binary (HB)] (PPHQ = 7.88 × 10-4, Pdepression status = 5.86 × 10-4); carbohydrate × genus Lactococcus (HB) (PPHQ = 0.0295, Pdepression status = 0.0150). We detected 41 common diet-gut microbiome interactions shared by GAD score and anxiety status, such as sugar × genus Parasutterella (rank normal transformed) (PGAD = 5.15 × 10-3, Panxiety status = 0.0347); tablespoons of raw vegetables per day × family Coriobacteriaceae (HB) (PGAD = 6.02 × 10-4, Panxiety status = 0.0345). Some common significant interactions shared by depression and anxiety were identified, such as overall beef intake × genus Sporobacter (HB).</p>
CONCLUSIONS: Our study results expanded our understanding of how to comprehensively consider the relationships for dietary habits-gut microbiome interactions with depression and anxiety.</p>
11 Keywords
- Animals
- Anxiety
- Anxiety Disorders
- Cattle
- Depression
- Diet
- Feeding Behavior
- Gastrointestinal Microbiome
- Genome-Wide Association Study
- Humans
- Microbiota
15 Authors
- Yao Yao
- Xin Qi
- Yumeng Jia
- Jing Ye
- Xiaomeng Chu
- Yan Wen
- Bolun Cheng
- Shiqiang Cheng
- Li Liu
- Chujun Liang
- Cuiyan Wu
- Xi Wang
- Yujie Ning
- Sen Wang
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
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