| Title: | Exposure to air pollution and risk of incident dementia in the UK Biobank |
| Journal: | Environmental Research |
| Published: | 8 Feb 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35149105/ |
| DOI: | https://doi.org/10.1016/j.envres.2022.112895 |
| URL: | http://manuscript.elsevier.com/S0013935122002225/pdf/S0013935122002225.pdf |
| Citations: | 45 (38 in last 2 years) as of 8 Aug 2024 |
Publication 12539
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Air pollution may cause inflammatory and oxidative stress damage to the brain, leading to neurodegenerative disease. The association between air pollution and dementia, and modification by apolipoprotein E genotype 4 (APOE-ε4) has yet to be fully investigated.</p>
OBJECTIVES: To examine associations of air pollution with three types of incident dementias (Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VAD)), and their potential modification by APOE-ε4 genotype.</p>
METHODS: The UK Biobank enrolled >500,000 participants (2006-2010) with ongoing follow-up. We used annual averages of air pollution (PM2.5, PM10, PM2.5-10, PM2.5absorbance, NO2, NOX) for 2010 scaled to interquartile ranges (IQR). We included individuals aged ≥60 years, with no dementia diagnosis prior to January 1, 2010. Time to incident dementia and follow-up time were reported from baseline (January 01, 2010) to last censor event (death, last hospitalization, or loss to follow-up). Cox proportional hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated to estimate the association of air pollutants and incident dementia, and modification of these associations by APOE-ε4.</p>
RESULTS: Our sample included 187,194 individuals (including N = 680 AD, N = 377 VAD, N = 63 FTD) with a mean follow-up of 7.04 years. We observed consistent associations of PM2.5 with greater risk of all-cause dementia (HR = 1.17, 95% CI: 1.10, 1.24) and AD (HR = 1.17, 95% CI: 1.06, 1.29). NO2 was also associated with greater risk of any incident dementia (HR = 1.18, 95% CI: 1.10, 1.25), AD (HR = 1.15, 95% CI: 1.04, 1.28) and VAD (HR = 1.18, 95% CI: 1.03, 1.35). APOE-ε4 did not modify the association between any air pollutants and dementia.</p>
DISCUSSION: PM2.5 and NO2 levels were associated with several types of dementia, and these associations were not modified by APOE-ε4. Findings from the UK Biobank support and extend to other epidemiological evidence for the potential association of air pollutants with detrimental brain health during aging.</p>
10 Keywords
- Air Pollutants
- Air Pollution
- Alzheimer Disease
- Biological Specimen Banks
- Environmental Exposure
- Humans
- Middle Aged
- Neurodegenerative Diseases
- Particulate Matter
- United Kingdom
5 Authors
- Kimberly L Parra
- Gene E Alexander
- David A Raichlen
- Yann C Klimentidis
- Melissa A Furlong
1 Application
| Application ID | Title |
|---|---|
| 21259 | The genetic basis for Alzheimer?s and neurodegenerative disease ? understanding etiology and interaction with other risk factors. |
Enabling scientific discoveries that improve human health