| Title: | Elevated Lipoprotein(a) and Risk of Atrial Fibrillation An Observational and Mendelian Randomization Study |
| Journal: | Journal of the American College of Cardiology |
| Published: | 1 Apr 2022 |
| DOI: | https://doi.org/10.1016/j.jacc.2022.02.018 |
| Citations: | 5 (3 in last 2 years) as of 8 Aug 2024 |
Publication 12438
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Abstract
Background Atrial fibrillation (AF) is a cardiac arrhythmia associated with an elevated risk of stroke, heart failure, and mortality. However, preventative therapies are needed with ancillary benefits on its cardiovascular comorbidities. Lipoprotein(a) (Lp[a]) is a recognized risk factor for atherosclerotic cardiovascular disease (ASCVD), which itself increases AF risk, but it remains unknown whether Lp(a) is a causal mediator of AF independent of ASCVD. Objectives This study investigated the role of Lp(a) in AF and whether it is independent of ASCVD. Methods Measured and genetically predicted Lp(a) levels were tested for association with 20,432 cases of incident AF in the UK Biobank (N = 435,579). Mendelian randomization analyses were performed by using -level data for AF from publicly available genome-wide association studies (N = 1,145,375). Results In the UK Biobank, each 50 nmol/L (23 mg/dL) increase in Lp(a) was associated with an increased risk of incident AF using measured Lp(a) (HR: 1.03; 95% CI: 1.02-1.04 ; P = 1.65 × 10-8) and genetically predicted Lp(a) (OR: 1.03; 95% CI: 1.02-1.05; P = 1.33 × 10-5). Mendelian randomization analyses using independent data replicated the effect (OR: 1.04 per 50 nmol/L Lp[a] increase; 95% CI: 1.03-1.05 per 50 nmol/L Lp[a] increase; P = 9.23 × 10-10). There was no evidence of risk-conferring effect from low-density lipoprotein cholesterol or triglycerides, and only 39% (95% CI: 27%-73%) of Lp(a) risk was mediated through ASCVD, suggesting that Lp(a) partly influences AF independent of its known effects on ASCVD. Conclusions Our findings implicate Lp(a) as a potential causal mediator in the development of AF which show that the effects of Lp(a) extend across myocardial tissues. Ongoing clinical trials for Lp(a)-lowering therapies should evaluate effects on AF prevention.</p>
11 Authors
- Pedrum Mohammadi-Shemirani
- Michael Chong
- Sukrit Narula
- Nicolas Perrot
- David Conen
- Jason D. Roberts
- Sébastien Thériault
- Yohan Bossé
- Matthew B. Lanktree
- Marie Pigeyre
- Guillaume Paré
1 Application
| Application ID | Title |
|---|---|
| 15255 | Identification of the shared biological and sociodemographic factors underlying cardiovascular disease and dementia risk |
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