| Title: | Plasma Caffeine Levels and Risk of Alzheimer's Disease and Parkinson's Disease: Mendelian Randomization Study |
| Journal: | Nutrients |
| Published: | 19 Apr 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35565667/ |
| DOI: | https://doi.org/10.3390/nu14091697 |
| URL: | https://www.mdpi.com/2072-6643/14/9/1697/pdf?version=1650434397 |
| Citations: | 26 (22 in last 2 years) as of 8 Aug 2024 |
Publication 12408
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
We leveraged genetic variants associated with caffeine metabolism in the two-sample Mendelian randomization framework to investigate the effect of plasma caffeine levels on the risk of Alzheimer's disease and Parkinson's disease. Genetic association estimates for the outcomes were obtained from the International Genomics of Alzheimer's Project, the International Parkinson's Disease Genomics consortium, the FinnGen consortium, and the UK Biobank. Genetically predicted higher plasma caffeine levels were associated with a non-significant lower risk of Alzheimer's disease (odds ratio 0.87; 95% confidence interval 0.76, 1.00; p = 0.056). A suggestive association was observed for genetically predicted higher plasma caffeine levels and lower risk of Parkinson's disease in the FinnGen consortium. but not in the International Parkinson's Disease Genomics consortium; no overall association was found (odds ratio 0.92; 95% confidence interval 0.77, 1.10; p = 0.347). This study found possible suggestive evidence of a protective role of caffeine in Alzheimer's disease. The association between caffeine and Parkinson's disease requires further study.</p>
9 Keywords
- Alzheimer Disease
- Caffeine
- Genome-Wide Association Study
- Humans
- Mendelian Randomization Analysis
- Odds Ratio
- Parkinson Disease
- Polymorphism, Single Nucleotide
- Risk Factors
3 Authors
- Susanna C. Larsson
- Benjamin Woolf
- Dipender Gill
1 Application
| Application ID | Title |
|---|---|
| 15825 | MR-Base: an online resource for Mendelian randomization using summary data |
Enabling scientific discoveries that improve human health