| Title: | Hypertension, a dementia polygenic risk score, APOE genotype, and incident dementia |
| Journal: | Alzheimer's & Dementia |
| Published: | 19 Apr 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35439339/ |
| DOI: | https://doi.org/10.1002/alz.12680 |
| Citations: | 9 (6 in last 2 years) as of 8 Aug 2024 |
Publication 12407
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Abstract
INTRODUCTION: There is inconsistent evidence on whether genetic risk for dementia modifies the association between hypertension and dementia.</p>
METHODS: In 198,965 dementia-free participants aged ≥60 years, Cox proportional-hazards models were used to investigate the association between hypertension and incident dementia. A polygenic risk score (PRS) based on 38 non-apolipoprotein E (APOE) single nucleotide polymorphisms and APOE ε4 status were used to determine genetic risk for dementia.</p>
RESULTS: Over 15 years follow-up, 6270 participants developed dementia. Hypertension was associated with a 19% increased risk of dementia (hazard ratio = 1.19, 95% confidence interval 1.11-1.27). The associations remained similar when stratifying by genetic risk, with no evidence for multiplicative interaction by dementia PRS (P = 0.20) or APOE ε4 status (P = 0.16). However, the risk difference between those with and without hypertension was larger among those at higher genetic risk.</p>
DISCUSSION: Hypertension was associated with an increased risk of dementia regardless of genetic risk for dementia.</p>
6 Keywords
- Apolipoprotein E4
- Apolipoproteins E
- Genotype
- Humans
- Hypertension
- Risk Factors
6 Authors
- Thomas J. Littlejohns
- Jennifer A. Collister
- Xiaonan Liu
- Lei Clifton
- Neo M. Tapela
- David J. Hunter
1 Application
| Application ID | Title |
|---|---|
| 33952 | Risk profiles for cancers; polygenic risk scores with and without non-genetic risk factors |
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