| Title: | Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study |
| Journal: | Journal of Cachexia Sarcopenia and Muscle |
| Published: | 21 Apr 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35445560/ |
| DOI: | https://doi.org/10.1002/jcsm.12857 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jcsm.12857 |
| Citations: | 45 (41 in last 2 years) as of 8 Aug 2024 |
Publication 12403
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors.</p>
METHODS: A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all-cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer.</p>
RESULTS: Excluding the first 2 years of follow-up (landmark analysis), mean follow-up was 9.1 years (inter-quartile range: 8.3; 9.7) for incidence and 9.3 (inter-quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was associated with a higher risk of dementia incidence and mortality independent of major confounding factors (P < 0.001). Individuals in the lowest quintile of grip strength had 72% [95% confidence interval (CI): 1.55; 1.92] higher incident dementia risk and 87% [95% CI: 1.55; 2.26] higher risk of dementia mortality compared with those in the highest quintile. Our PAF analyses indicate that 30.1% of dementia cases and 32.3% of dementia deaths are attributable to having low grip strength. The association between grip strength and dementia outcomes did not differ by lifestyle or sociodemographic factors.</p>
CONCLUSIONS: Lower grip strength was associated with a higher risk of all-cause dementia incidence and mortality, independently of important confounding factors.</p>
11 Keywords
- Biological Specimen Banks
- Cardiovascular Diseases
- Dementia
- Female
- Hand Strength
- Humans
- Incidence
- Male
- Middle Aged
- Prospective Studies
- United Kingdom
14 Authors
- Irene Esteban-Cornejo
- Frederick K. Ho
- Fanny Petermann-Rocha
- Donald M. Lyall
- David Martinez-Gomez
- Verónica Cabanas-Sánchez
- Francisco B. Ortega
- Charles H. Hillman
- Jason M.R. Gill
- Terence J. Quinn
- Naveed Sattar
- Jill P. Pell
- Stuart R. Gray
- Carlos Celis-Morales
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
Enabling scientific discoveries that improve human health