| Title: | Joint Exposure to Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism and Incident Type 2 Diabetes |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 12 May 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35552706/ |
| DOI: | https://doi.org/10.1210/clinem/dgac304 |
| URL: | https://academic.oup.com/jcem/article-pdf/107/8/e3186/44886461/dgac304.pdf |
| Citations: | 3 (2 in last 2 years) as of 8 Aug 2024 |
Publication 12374
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Abstract
CONTEXT: Whether the psychological wellbeing status could be a risk factor for type 2 diabetes is unclear.</p>
OBJECTIVE: We aimed to measure the association between combined psychological wellbeing factors and type 2 diabetes and investigate whether this association was modified by genetic predisposition.</p>
METHODS: Prospective cohort study from the UK Biobank. In total, 127 496 participants who completed a psychological wellbeing questionnaire and did not have type 2 diabetes at baseline (2006-2010) were included; among them, 88 584 (69.5%) were analyzed to determine their genetic predisposition. The main outcome measure was incident type 2 diabetes.</p>
RESULTS: During the median follow-up of 10.0 years, 2547 incident type 2 diabetes cases were documented. Moderate to extreme unhappiness, satisfaction score ≤3, presence of broad depression, and a neuroticism score ≥3 were all significantly and independently associated with an increased risk of diabetes. When considered as a combination indicator, compared with individuals in the highest quartile of the psychological wellbeing score, the fully adjusted hazard ratios (95% CI) of type 2 diabetes were 1.41 (1.21-1.65) in the third quartile, 1.45 (1.24-1.69) in the second quartile, and 1.73 (1.48-2.01) in the lowest quartile. In the stratified analysis, we observed significant interactions between age and physical activity, and type 2 diabetes (Pinteraction < .001 and 0.049, respectively). However, there was no significant interaction between the psychological wellbeing score and genetic susceptibility to diabetes (Pinteraction = .980).</p>
CONCLUSION: Worse overall psychological wellbeing was associated with a significantly increased risk of type 2 diabetes in a dose-response fashion regardless of genetic predisposition.</p>
8 Keywords
- Depression
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Humans
- Neuroticism
- Personal Satisfaction
- Prospective Studies
- Risk Factors
12 Authors
- Ying Sun
- Yuefeng Yu
- Haojie Zhang
- Bin Wang
- Chi Chen
- Yuying Wang
- Xiao Tan
- Jihui Zhang
- Yi Chen
- Fangzhen Xia
- Yingli Lu
- Ningjian Wang
1 Application
| Application ID | Title |
|---|---|
| 77740 | Environmental factors in adulthood, genetic predisposition, and human common diseases |
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