| Title: | Vitamin D deficiency and C-reactive protein: a bidirectional Mendelian randomization study |
| Journal: | International Journal of Epidemiology |
| Published: | 17 May 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35579027/ |
| DOI: | https://doi.org/10.1093/ije/dyac087 |
| URL: | https://academic.oup.com/ije/advance-article-pdf/doi/10.1093/ije/dyac087/43723941/dyac087.pdf |
| Citations: | 50 (45 in last 2 years) as of 8 Aug 2024 |
Publication 12370
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Abstract
BACKGROUND: Low vitamin D status is often associated with systemic low-grade inflammation as reflected by elevated C-reactive protein (CRP) levels. We investigated the causality and direction of the association between vitamin D status and CRP using linear and non-linear Mendelian randomization (MR) analyses.</p>
METHODS: MR analyses were conducted using data from 294 970 unrelated participants of White-British ancestry from the UK Biobank. Serum 25-hydroxyvitamin D [25(OH)D] and CRP concentrations were instrumented using 35 and 46 genome-wide significant variants, respectively.</p>
RESULTS: In non-linear MR analysis, genetically predicted serum 25(OH)D had an L-shaped association with serum CRP, where CRP levels decreased sharply with increasing 25(OH)D concentration for participants within the deficiency range (<25 nmol/L) and levelled off at ∼50 nmol/L of 25(OH)D (Pnon-linear = 1.49E-4). Analyses using several pleiotropy-robust methods provided consistent results in stratified MR analyses, confirming the inverse association between 25(OH)D and CRP in the deficiency range (P = 1.10E-05) but not with higher concentrations. Neither linear or non-linear MR analysis supported a causal effect of serum CRP level on 25(OH)D concentration (Plinear = 0.32 and Pnon-linear = 0.76).</p>
CONCLUSION: The observed association between 25(OH)D and CRP is likely to be caused by vitamin D deficiency. Correction of low vitamin D status may reduce chronic inflammation.</p>
8 Keywords
- C-Reactive Protein
- Genome-Wide Association Study
- Humans
- Inflammation
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Vitamin D
- Vitamin D Deficiency
2 Authors
- Ang Zhou
- Elina Hyppönen
1 Application
| Application ID | Title |
|---|---|
| 20175 | Nutrition, diet and health: examining causal associations and gene-environment interactions |
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