| Title: | Combined association of walking pace and grip strength with incident type 2 diabetes |
| Journal: | Scandinavian Journal of Medicine and Science in Sports |
| Published: | 3 Jun 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35612725/ |
| DOI: | https://doi.org/10.1111/sms.14197 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/sms.14197 |
| Citations: | 9 (9 in last 2 years) as of 8 Aug 2024 |
Publication 12350
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Abstract
The current study aims to investigate the combined association of walking pace and grip strength with incident type 2 diabetes (T2D). A total of 205 738 participants (mean age 56.6 ± 8.1 years, 115 139 [56.0%] women) without diagnosed or unknown diabetes at baseline from the UK Biobank study were included in this prospective study. Walking pace was self-reported as slow, average, or brisk. Grip strength was measured using a dynamometer and classified as weak, average, and strong. The combined association of walking pace and grip strength with incident T2D was investigated using Cox-proportional hazards models with a 2-year landmark analysis. The additive interaction was conducted by estimating relative excess risk due to interaction (RERI). After the median follow-up period of 5.4 years (interquartile range: 4.8-6.5), 5082 (2.5%) participants were diagnosed with T2D. Compared to brisk-strong individuals (reference group), people who were slow-weak had a higher risk of T2D (hazard ratio: 1.64 [95% CI, 1.42-1.89]) after adjusting for all covariates. There were dose-response gradients across both walking pace and grip strength variables. There was a modest amount of negative additive interaction (RERI; -0.06 [95% CI, -0.16; -0.01]. To conclude, slower pace and weaker grip strength were associated with a higher risk of developing T2D, independent of sociodemographics, lifestyle, and adiposity. Combining walking pace and grip strength might be a practical approach to screening people who are at increased risk of developing T2D.</p>
11 Keywords
- Diabetes Mellitus, Type 2
- Female
- Hand Strength
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Walking
- Walking Speed
6 Authors
- Jirapitcha Boonpor
- Solange Parra-Soto
- Fanny Petermann-Rocha
- Frederick K Ho
- Carlos Celis-Morales
- Stuart R. Gray
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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