| Title: | The effects of the interaction of genetic predisposition with lifestyle factors on bladder cancer risk |
| Journal: | BJU International |
| Published: | 20 Sep 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36053730/ |
| DOI: | https://doi.org/10.1111/bju.15880 |
| URL: | https://dspace.library.uu.nl/bitstream/handle/1874/431801/BJU_International_-_2022_-_Yu.pdf?sequence=1&isAllowed=y |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 12223
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Abstract
OBJECTIVES: To investigate the association of polygenic risk score (PRS) and bladder cancer (BC) risk and whether this PRS can be offset by a healthy lifestyle.</p>
METHODS: Individuals with BC (n = 563) and non-BC controls (n = 483 957) were identified in the UK Biobank, and adjusted Cox regression models were used. A PRS was constructed based on 34 genetic variants associated with BC development, while a healthy lifestyle score (HLS) was constructed based on three lifestyle factors (i.e., smoking, physical activity, and diet).</p>
RESULTS: Overall, a negative interaction was observed between the PRS and the HLS (P = 0.02). A 7% higher and 28% lower BC risk per 1-standard deviation (SD) increment in PRS and HLS were observed, respectively. A simultaneous increment of 1 SD in both HLS and PRS was associated with a 6% lower BC risk. In addition, individuals with a high genetic risk and an unfavourable lifestyle showed an increased BC risk compared to individuals with low genetic risk and a favourable lifestyle (hazard ratio 1.55, 95% confidence interval 1.16-1.91; P for trend <0.001). Furthermore, population-attributable fraction (PAF) analysis showed that 12%-15% of the BC cases might have been prevented if individuals had adhered to a healthy lifestyle.</p>
CONCLUSION: This large-scale cohort study shows that a genetic predisposition combined with unhealthy behaviours have a joint negative effect on the risk of developing BC. Behavioural lifestyle changes should be encouraged for people through comprehensive, multifactorial approaches, although high-risk individuals may be selected based on genetic risk.</p>
9 Authors
- Evan Yi-Wen Yu
- Yu-Xiang Liu
- Ya-Ting Chen
- Qiu-Yi Tang
- Siamak Mehrkanoon
- Shi-Zhi Wang
- Wen-Chao Li
- Maurice P. Zeegers
- Anke Wesselius
1 Application
| Application ID | Title |
|---|---|
| 55889 | Identification of SNPs for Urinary Bladder Cancer |
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