| Title: | Future Risk of Falls Induced by Ankle-foot Sprains History: An Observational and Mendelian Randomization Study. |
| Journal: | Sports Medicine and Health Science |
| Published: | 1 May 2024 |
| DOI: | https://doi.org/10.1016/j.smhs.2024.05.002 |
Publication 12174
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Abstract
Background Ankle-foot sprains are the most common musculoskeletal injuries, which can impair balance and theoretically increase the risk of falls, but still, there is a lack of evidence supporting the direct association between ankle-foot sprains and the future risk of falls. Methods UK Biobank cohort was utilized to measure the association between ankle-foot sprains and fall risk with covariates adjusted. Then, the two-sample Mendelian randomization (MR) analysis was applied based on the genetically predicated ankle-foot sprains from FinnGen to validate causal relationship. Finally, genetically predicated cerebellar neuroimaging features were used to explore the mediating role of maladaptive neuroplasticity between ankle-foot sprains and falls by two-step MR analyses. Results Patients with ankle-foot sprains history exhibited a slightly increased risk of falls than the matched controls before and after adjustment for covariates (odd ratio [OR] ranged from 1.632 to 1.658). Two-sample MR analysis showed that ankle-foot sprains led to a higher risk of falls (OR = 1.036) and a lower fractional anisotropy of superior cerebellar peduncle (SCP) (left, β = -0.052; right, β = -0.053). A trend of mediating effect was observed for the fractional anisotropy of right SCP in the causal effects of ankle-foot sprains on falls (β = 0.003). Conclusion The history of ankle-foot sprains is associated with a slightly increased risk of falls. These findings improve our understanding of the clinical consequences of ankle-foot sprains in terms of fall risk and suggest the importance of adopting more efficient strategies for managing residual functional deficits after the injuries.</p>
12 Authors
- Xiao'ao Xue
- Weichu Tao
- Qianru Li
- Yi Li
- Yiran Wang
- Le Yu
- Xicheng Gu
- Tian Xia
- Rong Lu
- Ru Wang
- He Wang
- Yinghui Hua
1 Application
| Application ID | Title |
|---|---|
| 62721 | Central nervous system adaptation in ankle instability. |
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