| Title: | Different cardiovascular risks associated with elevated creatinine-based eGFR and cystatin C-based eGFR |
| Journal: | npj Cardiovascular Health |
| Published: | 2 May 2024 |
| DOI: | https://doi.org/10.1038/s44325-024-00005-x |
Publication 12162
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Abstract
To compare the association of elevated estimated glomerular filtration rate (eGFR) based on creatinine (eGFRcr) and cystatin C (eGFRcys) with the risk of cardiovascular diseases (CVD) and chronic kidney diseases (CKD). 372,060 participants free of CVD and CKD in the UK Biobank were included. Participants were categorized into low, normal and high eGFR groups according to the age- and sex-specific 5th and 95th percentiles of eGFR. The primary outcome was incident CVD, defined as a combination of ischemic heart disease, stroke, heart failure, and atrial fibrillation. Thresholds for high eGFR varied with age and sex, ranging from 96.5 to 116.0 mL/min/1.73 m2 and 100.3 to 120.1 mL/min/1.73 m2 for eGFRcr and eGFRcys, respectively. During a median follow-up of 12.4 years, 39,855 (10.7%) participants developed CVD. Compared with normal eGFR levels, high eGFRcr levels were associated with a higher risk of CVD (HR, 1.19; 95% CI: 1.14-1.25), while high eGFRcys levels were associated with a lower risk of CVD (HR, 0.90; 95% CI: 0.85-0.95). Compared to normal eGFR levels, both high eGFRcr and high eGFRcys levels were related to a lower risk of CKD. Elevated eGFRcr levels were associated with a higher risk of CVD, and elevated eGFRcys levels were associated with a lower risk of CVD.</p>
10 Authors
- Mengyi Liu
- Ziliang Ye
- Panpan He
- Qimeng Wu
- Sisi Yang
- Yanjun Zhang
- Chun Zhou
- Yuanyuan Zhang
- Fan Fan Hou
- Xianhui Qin
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