| Title: | Pervasive Modulation of Obesity Risk by the Environment and Genomic Background |
| Journal: | Genes |
| Published: | 14 Aug 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30110940/ |
| DOI: | https://doi.org/10.3390/genes9080411 |
| URL: | https://www.mdpi.com/2073-4425/9/8/411/pdf?version=1534241925 |
| Citations: | 20 (6 in last 2 years) as of 8 Aug 2024 |
Publication 12067
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Abstract
The prevalence of the so-called diseases of affluence, such as type 2 diabetes or hypertension, has increased dramatically in the last two generations. Although genome-wide association studies (GWAS) have discovered hundreds of genes involved in disease etiology, the sudden increase in disease incidence suggests a major role for environmental risk factors. Obesity constitutes a case example of a modern trait shaped by contemporary environment, although with considerable debates about the extent to which gene-by-environment (G×E) interactions accentuate obesity risk in individuals following obesogenic lifestyles. Although interaction effects have been robustly confirmed at the FTO locus, accumulating evidence at the genome-wide level implicates a role for polygenic risk-by-environment interactions. Through a variety of analyses using the UK Biobank, we confirm that the genomic background plays a major role in shaping the expressivity of alleles that increase body mass index (BMI).</p>
3 Authors
- Sini Nagpal
- Greg Gibson
- Urko M Marigorta
1 Application
| Application ID | Title |
|---|---|
| 17984 | Genotype-environment interactions and sub-classification of disease |
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