| Title: | The Combination of Physical Activity and Sedentary Behaviors Modifies the Genetic Predisposition to Obesity |
| Journal: | Obesity |
| Published: | 21 Mar 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30900409/ |
| DOI: | https://doi.org/10.1002/oby.22417 |
| Citations: | 8 (4 in last 2 years) as of 8 Aug 2024 |
Publication 11989
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Abstract
OBJECTIVE: This study aimed to investigate whether the association between a validated genetic profile risk score for BMI (GPRS-BMI) (based on 93 single-nucleotide polymorphisms) and phenotypic obesity (BMI) was modified by the combined categories of physical activity (PA) and sedentary behaviors in a large population-based study.</p>
METHODS: This study included cross-sectional baseline data from 338,216 white European adult men and women aged 37 to 73 years. Interaction effects of GPRS-BMI with the combined categories of PA and sedentary behaviors on BMI were investigated.</p>
RESULTS: There was a significant interaction between GPRS-BMI and the combined categories of objectively measured PA and total sedentary behavior (P[interaction] = 3.5 × 10-6 ); among physically inactive and highly sedentary individuals, BMI was higher by 0.60 kg/m2 per 1-SD increase in GPRS-obesity (P = 8.9 × 10-50 ), whereas the relevant BMI difference was 38% lower among physically active individuals and those with low sedentary time (β: 0.37 kg/m2 ; P = 2.3 × 10-51 ). A similar pattern was observed for the combined categories of objective PA and TV viewing (inactive/high TV viewing β: 0.60 vs. active/low TV viewing β: 0.40 kg/m2 ; P[interaction] = 2.9 × 10-6 ).</p>
CONCLUSIONS: This study provides evidence that combined categories of PA and sedentary behaviors modify the extent to which genetic predisposition to obesity results in higher BMI.</p>
17 Keywords
- Adult
- Aged
- Body Mass Index
- Cohort Studies
- Cross-Sectional Studies
- Effect Modifier, Epidemiologic
- Exercise
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Obesity
- Polymorphism, Single Nucleotide
- Risk Factors
- Sedentary Behavior
- White People
12 Authors
- Carlos A. Celis-Morales
- Donald M. Lyall
- Mark E.S. Bailey
- Fanny Petermann-Rocha
- Jana Anderson
- Joey Ward
- Daniel F. Mackay
- Paul Welsh
- Jill P. Pell
- Naveed Sattar
- Jason M.R. Gill
- Stuart R. Gray
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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