| Title: | The impact of major depressive disorder on glycaemic control in type 2 diabetes: a longitudinal cohort study using UK Biobank primary care records |
| Journal: | BMC Medicine |
| Published: | 29 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38807170/ |
| DOI: | https://doi.org/10.1186/s12916-024-03425-9 |
| URL: | https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-024-03425-9 |
Publication 11961
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Abstract
BackgroundThis study evaluates longitudinal associations between glycaemic control, measured by mean and within-patient variability of glycated haemaglobin (HbA1c) levels, and major depressive disorder (MDD) in individuals with type 2 diabetes (T2D), focusing on the timings of these diagnoses.MethodsIn UK Biobank, T2D was defined using self-report and linked health outcome data, then validated using polygenic scores. Repeated HbA1c measurements (mmol/mol) over the 10 years following T2D diagnosis were outcomes in mixed effects models, with disease duration included using restricted cubic splines. Four MDD exposures were considered: MDD diagnosis prior to T2D diagnosis (pre-T2D MDD), time between pre-T2D MDD diagnosis and T2D, new MDD diagnosis during follow-up (post-T2D MDD) and time since post-T2D MDD diagnosis. Models with and without covariate adjustment were considered.ResultsT2D diagnostic criteria were robustly associated with T2D polygenic scores. In 11,837 T2D cases (6.9 years median follow-up), pre-T2D MDD was associated with a 0.92 increase in HbA1c (95% CI: [0.00, 1.84]), but earlier pre-T2D MDD diagnosis correlated with lower HbA1c. These pre-T2D MDD effects became non-significant after covariate adjustment. Post-T2D MDD individuals demonstrated increasing HbA1c with years since MDD diagnosis (β=0.51$$\beta =0.51$$, 95% CI: [0.17, 0.86]). Retrospectively, across study follow-up, within-patient variability in HbA1c was 1.16 (95% CI: 1.13-1.19) times higher in post-T2D MDD individuals.ConclusionsThe timing of MDD diagnosis is important for understanding glycaemic control in T2D. Poorer control was observed in MDD diagnosed post-T2D, highlighting the importance of depression screening in T2D, and closer monitoring for individuals who develop MDD after T2D.</p>
8 Authors
- Alexandra C. Gillett
- Saskia P. Hagenaars
- Dale Handley
- Francesco Casanova
- Katherine G. Young
- Harry Green
- Cathryn M. Lewis
- Jess Tyrrell
1 Application
| Application ID | Title |
|---|---|
| 82087 | Genetics and genetic epidemiology of brain-related traits and disorders, and their interplay with physical health |
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