| Title: | Hospital-treated infectious diseases, genetic susceptibility and risk of type 2 diabetes: A population-based longitudinal study |
| Journal: | Diabetes & Metabolic Syndrome Clinical Research & Reviews |
| Published: | 15 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38917709/ |
| DOI: | https://doi.org/10.1016/j.dsx.2024.103063 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 11849
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Abstract
BACKGROUND: The longitudinal association between infectious diseases and the risk of type 2 diabetes (T2D) remains unclear.</p>
METHODS: Based on the UK Biobank, the prospective cohort study included a total of 396,080 participants without diabetes at baseline. We determined the types and sites of infectious diseases and incident T2D using the International Classification of Diseases 10th Revision codes (ICD-10). Time-varying Cox proportional hazard model was used to assess the association. Infection burden was defined as the number of infection episodes over time and the number of co-occurring infections. Genetic risk score (GRS) for T2D consisted of 424 single nucleotide polymorphisms.</p>
RESULTS: During a median of 9.04 [IQR, 8.3-9.7] years of follow-up, hospital-treated infectious diseases were associated with a greater risk of T2D (adjusted HR [aHR] 1.54 [95 % CI 1.46-1.61]), with risk difference per 10,000 individuals equal to 154.1 [95 % CI 140.7-168.2]. The heightened risk persisted after 5 years following the index infection. Bacterial infection with sepsis had the strongest risk of T2D (aHR 2.95 [95 % CI 2.53-3.44]) among different infection types. For site-specific analysis, bloodstream infections posed the greatest risk (3.01 [95 % CI 2.60-3.48]). A dose-response association was observed between infection burden and T2D risk within each GRS tertile (p-trend <0.001). High genetic risk and infection synergistically increased the T2D risk.</p>
CONCLUSION: Infectious diseases were associated with an increased risk of subsequent T2D. The risk showed specificity according to types, sites, severity of infection and the period since infection occurred. A potential accumulative effect of infection was revealed.</p>
6 Authors
- Jiazhen Zheng
- Quan Yang
- Jinghan Huang
- Hengying Chen
- Junchun Shen
- Shaojun Tang
1 Application
| Application ID | Title |
|---|---|
| 97089 | Associations of physical multimorbidity patterns and heart structure with cognition and neuroimaging outcomes |
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