| Title: | The associations of leukocyte telomere length and intermediary cardiovascular phenotype with adverse cardiovascular outcomes in the white population |
| Journal: | Scientific Reports |
| Published: | 17 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38886520/ |
| DOI: | https://doi.org/10.1038/s41598-024-64997-3 |
| URL: | https://www.nature.com/articles/s41598-024-64997-3.pdf |
Publication 11840
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Abstract
The evidence about the associations of leukocyte telomere length (LTL) and intermediary cardiovascular phenotypes with adverse cardiovascular outcomes is inconclusive. This study assessed these relationships with cardiovascular imaging, electrocardiography, and the risks of sudden cardiac death (SCD), coronary events, and heart failure (HF) admission. We conducted a cross-sectional analysis of UK Biobank participants enrolled between 2006 and 2010. LTL was measured using quantitative polymerase chain reactions. Electronic health records were used to determine the incidence of SCD, coronary events, and HF admission. Cardiovascular measurements were made using cardiovascular magnetic resonance imaging and machine learning. The associations of LTL with SCD, coronary events, and HF admission and cardiac magnetic resonance imaging, electrocardiogram parameters of 33,043 and 19,554 participants were evaluated by multivariate regression. The median (interquartile range) follow-up period was 11.9 (11.2-12.6) years. Data was analyzed from January to May 2023. Among the 403,382 white participants without coronary artery disease or HF, 181,637 (45.0%) were male with a mean age of 57.1 years old. LTL was independently negatively associated with a risk of SCD (LTL third quartile vs first quartile: hazard ratio [HR]: 0.81, 95% confidence interval [CI]: 0.72-0.92), coronary events (LTL third quartile vs first quartile: HR: 0.88, 95% CI: 0.84-0.92), and HF admission (LTL fourth quartile vs first quartile: HR: 0.84, 95% CI: 0.74-0.95). LTL was also independently positively associated with cardiac remodeling, specifically left ventricular mass index, left-ventricular-end systolic and diastolic volumes, mean left ventricular myocardial wall thickness, left ventricular stroke volume, and with electrocardiogram changes along the negative degree of T-axis. Cross-sectional study results showed that LTL was positively associated with heart size and cardiac function in middle age, but electrocardiography results did not show these associations, which could explain the negative association between LTL and risk of SCD, coronary events, and HF admission in UK Biobank participants.</p>
17 Keywords
- Aged
- Cardiovascular Diseases
- Cross-Sectional Studies
- Death, Sudden, Cardiac
- Electrocardiography
- Female
- Heart Failure
- Humans
- Leukocytes
- Male
- Middle Aged
- Phenotype
- Risk Factors
- Telomere
- Telomere Homeostasis
- United Kingdom
- White People
12 Authors
- Ho-Gi Chung
- Pil-Sung Yang
- Seunghoon Cho
- Eunsun Jang
- Daehoon Kim
- Hee Tae Yu
- Tae-Hoon Kim
- Jae-Sun Uhm
- Jung-Hoon Sung
- Hui-Nam Pak
- Moon-Hyoung Lee
- Boyoung Joung
1 Application
| Application ID | Title |
|---|---|
| 77793 | The causal inference study to determine the association of genetically predicted biological, behavioral, ethnic factors with risk of atrial fibrillation and its associated complications. |
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