| Title: | Life's Essential 8 and risks of cardiovascular morbidity and mortality among individuals with type 2 diabetes: A cohort study |
| Journal: | Diabetes & Metabolic Syndrome Clinical Research & Reviews |
| Published: | 25 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38943931/ |
| DOI: | https://doi.org/10.1016/j.dsx.2024.103066 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 11798
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Abstract
BACKGROUND: The association of cardiovascular health levels, as measured by the Life's Essential 8 score, with cardiovascular disease (CVD) incidence and mortality among individuals with type 2 diabetes (T2D) has not been fully elucidated.</p>
METHODS: This cohort study included 15,118 participants with T2D from the UK Biobank who were free of CVD and cancer at baseline. The cardiovascular health of participants was evaluated using the Life's Essential 8 score, categorizing their health levels into low, moderate, and high based on this assessment.</p>
RESULTS: During a median follow-up period of 13.0 years, we observed a total of 4421 cases of CVD, comprising 3467 cases of coronary heart disease (CHD), 811 cases of stroke, 1465 cases of heart failure (HF), and 523 cases of CVD mortality. Compared to participants with low cardiovascular health, those with high cardiovascular health had a 52 %, 50 %, 47 %, 67 %, and 51 % lower risk of CVD, CHD, stroke, HF, and CVD mortality, respectively. Among the components of the Life's Essential 8 score, body mass index showed the highest population attributable risk of 12.1 %. Similar findings were observed in joint analyses of cardiovascular health and diabetes severity status.</p>
CONCLUSIONS: This study emphasizes the importance of maintaining good cardiovascular health among individuals with T2D to reduce their risk of CVD incidence and mortality.</p>
8 Authors
- Hanzhang Wu
- Jiahe Wei
- Shuai Wang
- Wenjuan Chen
- Liangkai Chen
- Jihui Zhang
- Ningjian Wang
- Xiao Tan
1 Application
| Application ID | Title |
|---|---|
| 55177 | Role of sleep and circadian rhythm in treatment efficacy of antidiabetics |
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