| Title: | Reassessing the Impact of Coffee Consumption on Liver Disease: Insights from a Large-Scale Cohort Study with IPTW Adjustment |
| Journal: | Nutrients |
| Published: | 26 Jun 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38999772/ |
| DOI: | https://doi.org/10.3390/nu16132020 |
| URL: | https://www.mdpi.com/2072-6643/16/13/2020/pdf?version=1719396297 |
Publication 11789
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Abstract
Coffee consumption is globally widespread and has become a lifestyle habit. This study investigated coffee consumption and liver-related survival in a large cohort of 455,870 individuals with UK biobank, categorized into without steatosis, metabolic dysfunction-associated steatotic liver disease (MASLD), and MASLD and increased alcohol intake (MetALD). Inverse probability of treatment weighting (IPTW) adjusted for confounding variables was used, followed by Kaplan-Meier analysis. Moderate coffee consumption (1-2 cups per day) was associated with lower all-cause mortality across the entire cohort, without the steatosis, MASLD (p < 0.0001), and MetALD cohorts (p = 0.0047 for pre-IPTW, p = 0.027 for post-IPTW). Before IPTW adjustment, consuming one or more cups of coffee per day appeared to significantly reduce liver-related mortality in the overall (p = 0.015) and MASLD cohorts (p = 0.011). However, post-IPTW application, no significant differences in liver-related mortality were observed between the coffee intake groups (p = 0.778, 0.319, 0.564, 0.238 for each group). While increased coffee consumption initially seemed to reduce liver-related mortality, after IPTW adjustment, only all-cause mortality significantly decreased (p < 0.0001 and p = 0.027). These findings suggest that previous studies might have overestimated the favorable effect of coffee intake on chronic liver disease due to confounding factors.</p>
12 Keywords
- Adult
- Aged
- Coffee
- Cohort Studies
- Female
- Humans
- Kaplan-Meier Estimate
- Liver Diseases
- Male
- Middle Aged
- Risk Factors
- United Kingdom
5 Authors
- Keungmo Yang
- Young Chang
- Soung Won Jeong
- Jae Young Jang
- Tom Ryu
1 Application
| Application ID | Title |
|---|---|
| 117214 | Research on the prognostic impact of various metabolic factors on chronic liver disease and liver cancer to explore novel therapeutic targets. |
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