| Title: | Lower plasma linoleic acids as a risk factor for gout: an integrated analysis of population-based cohort and genetic data |
| Journal: | Food & Function |
| Published: | 15 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38934729/ |
| DOI: | https://doi.org/10.1039/d4fo00987h |
Publication 11780
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Abstract
Background: Gout is a nutrition-related, highly prevalent inflammatory arthritis with undesirable effects on the quality of life. The relationships between circulating fatty acids (FAs) and gout remain poorly understood. Method: We included 268 174 participants with plasma FAs measured using nuclear magnetic resonance at the baseline (2006-2010) from the UK Biobank, of which 15 194 participants had repeated measures of FAs between 2012 and 2013. Cox proportional hazards models were used to assess the association of the baseline and longitudinal changes in relative levels of plasma FAs (% total FAs) with incident gout. Mendelian randomization (MR) analyses were conducted to assess the potential causality of the examined association. Results: Over a median follow-up of 12.8 years, 5160 incident cases of gout occurred. Baseline polyunsaturated fatty acids (PUFAs), n-6 PUFAs, and linoleic acids (LAs) were inversely associated with incident gout (all P-trend values < 0.0001). Baseline monounsaturated fatty acids (MUFAs), n-3 PUFAs, and docosahexaenoic acids (DHAs) were positively associated with incident gout (all P-trend values < 0.0001). Longitudinal increments of n-6 PUFAs and LAs were associated with a lower risk of subsequent gout, whereas an increment of n-3 PUFAs was associated with a higher risk. In two-sample MR analyses, genetically determined higher levels of PUFAs, n-6 PUFAs, and LAs were associated with a decreased risk of gout (all P values < 0.05). Conclusions: Our findings consistently indicate a causal relationship of elevated levels of n-6 PUFAs, especially LAs, with a reduced risk of gout.</p>
13 Keywords
- Adult
- Aged
- Cohort Studies
- Fatty Acids, Unsaturated
- Female
- Gout
- Humans
- Linoleic Acid
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Risk Factors
- United Kingdom
15 Authors
- Hao-Wei Tao
- Zhong-Yue Liu
- Wei Jiang
- Meng-Yuan Miao
- Jie-Qiong Lyu
- Miao Zhao
- Jie Zhu
- Jin-Si Chen
- Hong-Zhen Du
- Zeng-Ning Li
- Zhengbao Zhu
- Jing Yang
- Li-Qiang Qin
- Wei Chen
- Guo-Chong Chen
1 Application
| Application ID | Title |
|---|---|
| 90087 | Role of environmental and host factors and their interplays in the development and progression of chronic diseases |
Enabling scientific discoveries that improve human health