| Title: | Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank |
| Journal: | Nature Human Behaviour |
| Published: | 2 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38956227/ |
| DOI: | https://doi.org/10.1038/s41562-024-01903-x |
Publication 11729
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Abstract
Suicide is a global public health challenge, yet considerable uncertainty remains regarding the associations of both behaviour-related and physiological factors with suicide attempts (SA). Here we first estimated polygenic risk scores (PRS) for SA in 334,706 UK Biobank participants and conducted phenome-wide association analyses considering 2,291 factors. We identified 246 (63.07%) behaviour-related and 200 (10.41%, encompassing neuroimaging, blood and metabolic biomarkers, and proteins) physiological factors significantly associated with SA-PRS, with robust associations observed in lifestyle factors and mental health. Further case-control analyses involving 3,558 SA cases and 149,976 controls mirrored behaviour-related associations observed with SA-PRS. Moreover, Mendelian randomization analyses supported a potential causal effect of liability to 58 factors on SA, such as age at first intercourse, neuroticism, smoking, overall health rating and depression. Notably, machine-learning classification models based on behaviour-related factors exhibited high discriminative accuracy in distinguishing those with and without SA (area under the receiver operating characteristic curve 0.909 ± 0.006). This study provides comprehensive insights into diverse risk factors for SA, shedding light on potential avenues for targeted prevention and intervention strategies.</p>
16 Authors
- Bei Zhang
- Jia You
- Edmund T. Rolls
- Xiang Wang
- Jujiao Kang
- Yuzhu Li
- Ruohan Zhang
- Wei Zhang
- Huifu Wang
- Shitong Xiang
- Chun Shen
- Yuchao Jiang
- Chao Xie
- Jintai Yu
- Wei Cheng
- Jianfeng Feng
1 Application
| Application ID | Title |
|---|---|
| 19542 | Identifying multi-level biomarkers and disease mechanisms for major mental disorders |
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