| Title: | Association between grip strength and walking pace with incidence of degenerative cervical myelopathy: a UK biobank observational study |
| Journal: | European Spine Journal |
| Published: | 9 Jul 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38980365/ |
| DOI: | https://doi.org/10.1007/s00586-024-08374-8 |
Publication 11685
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Abstract
PurposeThis study investigates the association between handgrip strength, walking pace, and the incidence of degenerative cervical myelopathy (DCM) using the UK Biobank dataset.MethodsWe analyzed data from 364,716 UK Biobank participants without prior neurological conditions. Handgrip strength was measured with a dynamometer, and walking pace was self-reported. Cox proportional hazards models assessed hazard ratios (HRs) and 95% confidence intervals (CIs) for DCM development.ResultsThe cohort, with an average age of 56.2 years (SD, 8.1) and 47.4% male, was followed for a median of 12.6 years. During this period, 3,993 participants (1.1%) developed DCM. A significant inverse correlation was found between handgrip strength and DCM incidence (P for trend < 0.001), with decreasing HRs for DCM across quartiles of increasing grip strength: HRs were 0.70 (95% CI: 0.64-0.76), 0.62 (95% CI: 0.57-0.68), and 0.59 (95% CI: 0.54-0.66) for the second, third, and fourth quartiles, respectively. Participants with average or brisk walking paces had a lower DCM risk (HR, 0.55; 95% CI: 0.50-0.61 and HR, 0.48; 95% CI: 0.43-0.54) compared to slow walkers. The greatest risk reduction was in those with both higher handgrip strength and faster pace (HR, 0.39; 95% CI: 0.34-0.44).ConclusionsHandgrip strength and walking pace are inversely associated with DCM incidence, suggesting their potential as cost-effective screening tools for identifying individuals at risk for DCM.</p>
8 Authors
- Lin Chengkai
- Li Junhong
- Zhu Zhengya
- Zhou Jiaxiang
- Wang Fuan
- Wei Fuxin
- Zhou Zhiyu
- Shaoyu Liu
1 Application
| Application ID | Title |
|---|---|
| 89289 | The study of lifestyles, environment factors and genetic variants associated with degenerative spinal disorders. |
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