| Title: | Adiposity and sex-specific cancer risk |
| Journal: | Cancer Cell |
| Published: | 1 Jun 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37311415/ |
| DOI: | https://doi.org/10.1016/j.ccell.2023.05.010 |
| URL: | http://www.cell.com/article/S1535610823001770/pdf |
| Citations: | 9 (9 in last 2 years) as of 8 Aug 2024 |
Publication 11526
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Abstract
Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat distribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.</p>
6 Authors
- Mathias Rask-Andersen
- Emma Ivansson
- Julia Höglund
- Weronica E Ek
- Torgny Karlsson
- Åsa Johansson
1 Application
| Application ID | Title |
|---|---|
| 15152 | Interaction between diet, food preference and lifestyle with genetic factors influencing body mass, body adiposity and obesity |
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