| Title: | Low Circulating Valine Associate With High Risk of Hip Fractures |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 13 May 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37178220/ |
| DOI: | https://doi.org/10.1210/clinem/dgad268 |
| URL: | https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgad268/50456670/dgad268.pdf |
Publication 11446
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
CONTEXT: Hip fractures constitute a major health concern. An adequate supply of amino acids is crucial to ensure optimal acquisition and remodeling of bone. Circulating amino acid levels have been proposed as markers of bone mineral density, but data on their ability to predict incident fractures are scarce.</p>
OBJECTIVES: To investigate the associations between circulating amino acids and incident fractures.</p>
METHODS: We used UK Biobank (n = 111 257; 901 hip fracture cases) as a discovery cohort and the Umeå Fracture and Osteoporosis (UFO) hip fracture study (hip fracture cases n = 2225; controls n = 2225) for replication. Associations with bone microstructure parameters were tested in a subsample of Osteoporotic Fractures in Men Sweden (n = 449).</p>
RESULTS: Circulating valine was robustly associated with hip fractures in the UK Biobank (HR per SD increase 0.79, 95% CI 0.73-0.84), and this finding was replicated in the UFO study (combined meta-analysis including 3126 incident hip fracture cases, odds ratio per SD increase 0.84, 95% CI 0.80-0.88). Detailed bone microstructure analyses showed that high circulating valine was associated with high cortical bone area and trabecular thickness.</p>
CONCLUSION: Low circulating valine is a robust predictor of incident hip fractures. We propose that circulating valine may add information for hip fracture prediction. Future studies are warranted to determine whether low valine is causally associated with hip fractures.</p>
8 Authors
- Louise Grahnemo
- Anna L Eriksson
- Maria Nethander
- Robert Johansson
- Mattias Lorentzon
- Dan Mellström
- Ulrika Pettersson-Kymmer
- Claes Ohlsson
1 Application
| Application ID | Title |
|---|---|
| 51784 | Genetic markers and biomarkers for age-related diseases |
Enabling scientific discoveries that improve human health