| Title: | Estimated 24-h urinary sodium excretion and risk of end-stage kidney disease |
| Journal: | iScience |
| Published: | 23 Apr 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37216108/ |
| DOI: | https://doi.org/10.1016/j.isci.2023.106728 |
| URL: | http://www.cell.com/article/S2589004223008052/pdf |
Publication 11371
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Abstract
The association between sodium intake and long-term kidney disease endpoints is debated and yet to be proven. We aimed to investigate the associations of estimated 24-h urinary sodium excretion, reflecting daily sodium intake, with the incidence of end-stage kidney disease (ESKD). In this prospective cohort study including 444,375 UK Biobank participant, 865 (0.2%) ESKD events occurred after median follow-up of 12.7 years. For every 1 g increment in estimated 24-h urinary sodium excretion, multivariable-adjusted hazard ratio for incident ESKD was 1.09 (95% confidence interval 0.94-1.26). Nonlinear associations were not detected with restricted cubic splines. The null findings were confirmed by a series of sensitivity analyses, which attenuated potential bias from measurement errors of the exposure, regression dilution, reverse causality, and competing risks. In conclusion, there is insufficient evidence that estimated 24-h urinary sodium excretion is associated with the incidence of ESKD.</p>
12 Authors
- Ying Shan
- Yong Bai
- Jingwen Zhang
- Yueqi Lu
- Sike Yu
- Congying Song
- Juehan Liu
- Min Jian
- Junjie Xu
- Changhai Ding
- Zuying Xiong
- Xiaoyan Huang
1 Application
| Application ID | Title |
|---|---|
| 73684 | Identifying risk factors of complex diseases: observational and genetic associations |
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