| Title: | Female Reproductive Factors and Risk of New-Onset Heart Failure Findings From UK Biobank |
| Journal: | JACC Heart Failure |
| Published: | 19 Apr 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37086244/ |
| DOI: | https://doi.org/10.1016/j.jchf.2023.02.019 |
Publication 11360
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Abstract
BACKGROUND: A comprehensive evaluation of woman-specific risk factors in relation to incident heart failure (HF) is limited.</p>
OBJECTIVES: This study sought to investigate the association of multiple female reproductive factors with the risk of HF.</p>
METHODS: Between 2007 and 2010, 229,026 women (mean age: 56.5 years) without prevalent HF from the UK Biobank cohort were included and followed until December 2020. The relation between (self-reported) reproductive factors and HF was analyzed using Cox proportional hazards models with adjustment for potential confounding.</p>
RESULTS: Menarche at age <12 years, compared to age 12-13 years, carried a 9% larger risk of HF (HR: 1.09 [95% CI: 1.01-1.18]). Younger age at menopause was associated with a higher risk of HF (HRage <45 y vs 50-51 y: 1.15 [95% CI: 1.03-1.28]; HRage 45-49 y vs 50-51 y: 1.11 [95% CI: 1.01-1.23]). Younger maternal age at first live birth (HRage <21 y vs 24-26 y: 1.42 [95% CI: 1.28-1.59]; HRage 21-23 y vs 24-26 y: 1.14 [95% CI: 1.03-1.26]) and at last live birth (HRage <26 y vs 29-31 y: 1.19 [95% CI: 1.07-1.33]) were associated with higher risk of HF. Compared to women with 1 or 2 children, having 3 or 4 children (HR: 1.09 [95% CI: 1.02-1.17]) or >4 children (HR: 1.24 [95% CI: 1.05-1.47]) was associated with higher HF risk. Experiencing miscarriages or abortions was not significantly associated with incident HF, whereas experiencing 1 stillbirth and recurrent stillbirths conferred a 20% and 43% larger risk of HF, respectively, compared to no stillbirth.</p>
CONCLUSIONS: The findings emphasize the importance of female reproductive history in the assessment of HF risk.</p>
5 Authors
- Fang Zhu
- Hongchao Qi
- Maxime Bos
- Eric Boersma
- Maryam Kavousi
1 Application
| Application ID | Title |
|---|---|
| 58237 | Etiology and prevention of atrial fibrillation and its complications using a multidimensional and sex-specific approach. |
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