| Title: | Defining left ventricular remodeling using lean body mass allometry: a UK Biobank study |
| Journal: | European Journal of Applied Physiology |
| Published: | 8 Jan 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36617359/ |
| DOI: | https://doi.org/10.1007/s00421-022-05125-9 |
| URL: | https://lirias.kuleuven.be/bitstream/20.500.12942/710889/2/Revised%20manuscript.pdf |
Publication 10943
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Abstract
PurposeThe geometric patterns of ventricular remodeling are determined using indexed left ventricular mass (LVM), end-diastolic volume (LVEDV) and concentricity, most often measured using the mass-to-volume ratio (MVR). The aims of this study were to validate lean body mass (LBM)-based allometric coefficients for scaling and to determine an index of concentricity that is independent of both volume and LBM.MethodsParticipants from the UK Biobank who underwent both CMR and dual-energy X-ray absorptiometry (DXA) during 2014-2015 were considered (n = 5064). We excluded participants aged ≥ 70 years or those with cardiometabolic risk factors. We determined allometric coefficients for scaling using linear regression of the logarithmically transformed ventricular remodeling parameters. We further defined a multiplicative allometric relationship for LV concentricity (LVC) adjusting for both LVEDV and LBM.ResultsA total of 1638 individuals (1057 female) were included. In subjects with lower body fat percentage (< 25% in males, < 35% in females, n = 644), the LBM allometric coefficients for scaling LVM and LVEDV were 0.85 ± 0.06 and 0.85 ± 0.03 respectively (R2 = 0.61 and 0.57, P < 0.001), with no evidence of sex-allometry interaction. While the MVR was independent of LBM, it demonstrated a negative association with LVEDV in (females: r = − 0.44, P < 0.001; males: − 0.38, P < 0.001). In contrast, LVC was independent of both LVEDV and LBM [LVC = LVM/(LVEDV0.40 × LBM0.50)] leading to increased overlap between LV hypertrophy and higher concentricity.ConclusionsWe validated allometric coefficients for LBM-based scaling for CMR indexed parameters relevant for classifying geometric patterns of ventricular remodeling.</p>
12 Authors
- Bruna Gomes
- Kristofer Hedman
- Tatiana Kuznetsova
- Nicholas Cauwenberghs
- David Hsu
- Yukari Kobayashi
- Erik Ingelsson
- David Oxborough
- Keith George
- Michael Salerno
- Euan Ashley
- Francois Haddad
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