| Title: | Understanding the Complex Interactions between Coffee, Tea Intake and Neurologically Relevant Tissues Proteins in the Development of Anxiety and Depression |
| Journal: | The journal of nutrition, health & aging |
| Published: | 3 Dec 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36519770/ |
| DOI: | https://doi.org/10.1007/s12603-022-1869-6 |
Publication 10776
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Abstract
ObjectivesCoffee and tea intake might be associated with psychiatry diseases. However, it is unclear whether the effect of coffee/tea on anxiety and depression depending on the different types of proteins.DesignThis was a cross-sectional study.SettingOur datasets were downloaded from online.ParticipantsPhenotypic and genotypic data for coffee intake(N=376,196) and tea intake (N=376,078) were derived from UK Biobank. GWAS data of proteins (N=1,537) from neurologically relevant tissues (brain, cerebrospinal fluid (CSF) and plasma) were obtained from a recently published study.MeasurementsMultivariate linear analysis was then used to evaluate the potential interaction effect between coffee/tea intake and proteins polygenetic risk score (PRS) on the risks of anxiety and depression controlling for age, sex, Townsend deprivation index (TDI), smoke, drinking and education level.Results34 coffee intake-proteins interactions and 15 tea intake-proteins interactions were observed in anxiety individuals, such as coffee intake-c-Jun interaction (β=0.0169, P=4.131×10−3), coffee intake-Fas interaction (β=−0.0190, P=8.132×10−4), tea intake-sL-Selectin interaction (β=0.0112, P=5.412×10−3) and tea intake-IL-1F6 (β=0.0083, P=4.471×10−2). 25 coffee intake-proteins and 14 tea intake-proteins interactions were observed in depression individuals, including coffee intake- IL-1 sRI (β=0.0171, P=4.888×10−3) and coffee intake-NXPH1 interaction (β=0.0156, P=9.819×10−3), tea intake-COLEC12 interaction (β=0.0127, P=3.280×10−3), and tea intake-Layilin interaction (β=0.0117, P=7.926×10−3).ConclusionsOur results suggested the important role of multiple proteins in neurologically relevant tissues in the associations between coffee/tea intake and psychiatry diseases, providing entry points to explore the mechanisms underlying anxiety and depression.</p>
17 Authors
- L. Liu
- B. Cheng
- J. Ye
- X. Qi
- S. Cheng
- P. Meng
- Y. Chen
- X. Yang
- Y. Yao
- H. Zhang
- Z. Zhang
- J. Zhang
- C. Li
- C. Pan
- Y. Wen
- Y. Jia
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
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