| Title: | A General Cognitive Ability Factor for the UK Biobank |
| Journal: | Behavior Genetics |
| Published: | 15 Nov 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36378351/ |
| DOI: | https://doi.org/10.1007/s10519-022-10127-6 |
| URL: | https://hal.science/hal-03856587/file/G_Factor_Manuscript_PsyArXiv-1.pdf |
| Citations: | 5 (3 in last 2 years) as of 8 Aug 2024 |
Publication 10685
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
UK Biobank participants do not have a high-quality measure of intelligence or polygenic scores (PGSs) of intelligence to simultaneously examine the genetic and neural underpinnings of intelligence. We created a standardized measure of general intelligence (g factor) relative to the UK population and estimated its quality. After running a GWAS of g on UK Biobank participants with a g factor of good quality and without neuroimaging data (N = 187,288), we derived a g PGS for UK Biobank participants with neuroimaging data. For individuals with at least one cognitive test, the g factor from eight cognitive tests (N = 501,650) explained 29% of the variance in cognitive test performance. The PGS for British individuals with neuroimaging data (N = 27,174) explained 7.6% of the variance in g. We provided high-quality g factor estimates for most UK Biobank participants and g factor PGSs for UK Biobank participants with neuroimaging data.</p>
5 Authors
- Camille Michèle Williams
- Ghislaine Labouret
- Tobias Wolfram
- Hugo Peyre
- Franck Ramus
1 Application
| Application ID | Title |
|---|---|
| 46007 | Brain allometry and asymmetries as intermediate phenotypes between genetic and environmental factors, and cognitive function and mental health |
Enabling scientific discoveries that improve human health