| Title: | Polygenic Risk Score and Risk Factors for Preeclampsia and Gestational Hypertension |
| Journal: | Journal of Personalized Medicine |
| Published: | 3 Nov 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36579561/ |
| DOI: | https://doi.org/10.3390/jpm12111826 |
| URL: | https://www.mdpi.com/2075-4426/12/11/1826/pdf?version=1667447610 |
| Citations: | 5 (5 in last 2 years) as of 8 Aug 2024 |
Publication 10654
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Abstract
Preeclampsia and gestational hypertensive disorders (GHD) are common complications of pregnancy that adversely affect maternal and offspring health, often with long-term consequences. High BMI, advanced age, and pre-existing conditions are known risk factors for GHD. Yet, assessing a woman's risk of GHD based on only these characteristics needs to be reevaluated in order to identify at-risk women, facilitate early diagnosis, and implement lifestyle recommendations. This study demonstrates that a risk score developed with machine learning from the case-control genetics dataset can be used as an early screening test for GHD. We further confirm BMI as a risk factor for GHD and investigate a relationship between GHD and genetically constructed anthropometric measures and biomarkers. Our results show that polygenic risk score can be used as an early screening tool that, together with other known risk factors and medical history, would assist in identifying women at higher risk of GHD before its onset to enable stratification of patients into low-risk and high-risk groups for monitoring and preventative programs to mitigate the risks.</p>
6 Authors
- Marija Majda Perišić
- Klemo Vladimir
- Sarah Karpov
- Mario Štorga
- Ali Mostashari
- Raya Khanin
1 Application
| Application ID | Title |
|---|---|
| 30281 | Study of the effect of genetic variants in vitamin and mineral metabolic pathways on health outcomes |
Enabling scientific discoveries that improve human health